Professor, Biomedical, Engineering
Research Professor, Pharmacology
Director, BioMolecular Engineering Resource Center
B.S.,Physics Purdue University,
PhD., Nuclear Physics, University of Colorado

Research interests

The syntactic and semantic structure in the genetic information in the biolmolecular sequences, structures, and their evolution.

1. Hartman, Hyman, Favaretto, Paola and Smith, Temple F. (2005). The archaeal origins of the eukaryotic translational system. Archaea, in press.
2. Favaretto, Paola, Bhutkar, Arjun, Smith, Temple. (2005). Constraining ribosomal RNA conformational space. Nucleic Acids Research 33(16), 5106-5111.
3. Vishwanath, Prashanth, Hartman, Hyman, Mohr, Scott C. and Smith, Temple F. (2004). Ribosomal protein-sequence block structure suggests complex prokaryotic evolution with implications for the origin of eukaryotes. Molecular Phylogenetics and Evolution 33, 615-625.
4. Smith, Temple F and Mohr, Scott C. (2004). Language evolution and social strata. Science 304, 1243.
5. Venkatesan, Kavitha, McManus, Heather R., Mello, Craig C., Smith, Temple F. and Hansen, Ulla. (2003). Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead. Nucleic Acids Research 31(15), 4304-4316.
6. Bienkowska, Jadwiga, Hartman, Hyman and Smith, Temple F. (2003). A search method for homologs of small proteins, Ubiquitin-like proteins in prokaryotic cells? Protein Engineering 16 (12), 897-904.
7. Smith, Temple F. (2002). The challenges facing genomic informatics. In Current Topics in Computational Molecular Biology, Tao Jiang, Ying Xu and Michael Q. Zhang, eds., pp. 3-8, MIT Press, Cambridge, Massachusetts.
8. He, Hongxian, McAllister, Gregory and Smith, Temple F. (2002). Triage protein fold prediction. PROTEINS 48, 654-663.
9. Graber, Joel, McAllister, Gregory D. and Smith, Temple F. (2002). Probabilistic prediction of Saccharomyces cerevisiae mRNA 3\u2019-processing sites. Nucleic Acids Research 30(8), 1851-1858.
10. Plasterer, Thomas N., Smith, Temple F. and Mohr, Scott C. (2001). Survey of human mitochondrial diseases using new genomic/proteomic tools. Genome Biology 2(6).
11. Moreno-Hagelsieb, Gabriel, Treviño, Victor, Pérez-Rueda, Ernesto, Smith, Temple F. and Collado-Vides, Julio. (2001). Transcription unit conservation in the three domains of life: a perspective from Escherichia coli. Trends in Genetics 17 (4), 175-177.
12. Hisbergues, Michael, Gaitatzes, Chrysanthe G., Joset, Francoise, Bedu, Sylvie and Smith, Temple F. (2001). A noncanonical WD-repeat protein from the cyanobacterium Synechocystis PCC6803: Structural and functional study. Protein Science 10, 293-300.
13. Bienkowska, Jadwiga, He, Hongxian and Smith, Temple F. (2001). Automatic pattern embedding in protein structure models. IEEE Intelligent Systems in Biology 16 (6), 21-25.
14. Yu, Lihua, Gaitatzes, Chrysanthe, Neer, Eva J. and Smith, Temple F. (2000). Thirty-plus functional families from a single motif. Protein Science 9, 2470-2476.
15. Salgado, Heladia, Moreno-Hagelsieb, Gabriel, Smith, Temple F. and Collado-Vides, Julio. (2000). Operons in Escherichia coli: Genomic analyses and predictions. Proceedings of the National Academy of Sciences 97, 6652-6657.
16. Neer, Eva J. and Smith, Temple F. (2000). A groovy new structure. PNAS 97(3), 960-962.
17. Das, Sudeshna and Smith, Temple F. (2000). Identifying nature\u2019s Lego set. In Advances in Protein Chemistry, Vol. 54 , \u201cAnalysis of Amino Acid Sequences\u201d, Peer Bork, ed., pp. 159-183, Academic Press.
18. Cosenza, Larry, Rosenbach, Andrew, White, James V., Murphy, John R. and Smith, Temple. (2000). Comparative model building of Interleukin-7 using Interleukin-4 as a template: A structural hypothesis that displays atypical surface chemistry in helix D important for receptor activation. Protein Science 9, 1-11.
19. Bienkowska, Jadwiga, Yu, Lihua, Zarakhovich, Sophia, Rogers, Robert G. Jr. & Smith, Temple F. (2000). Protein fold recognition by total alignment probability. Proteins 40(3), 451-462.
20. Bienkowska, Jadwiga, Yu, Lihua, Zarakhovich, Sophia, Rogers, Robert G. Jr. & Smith, Temple F. (2000). Comprehensive statistical method for protein fold recognition. In RECOMB 2000: Proceedings of the Fourth Annual International Conference on Computational Molecular Biology. R. Shamir, S. Miyano, S. Istrail, P. Pevzner & M. Waterman, eds., pp. 76-85.
21. Smith, Temple F., Gaitatzes, Chrysanthe, Saxena, Kumkum and Neer, Eva J. (1999). The WD-repeat: A common architecture for diverse functions. Trends in the Biological Sciences 24 (5), 181-185.
22. Smith, Temple F. (1999). The art of matchmaking: sequence alignment methods and their structural implications. Structure 7 (1), R7-R12.
23. Lathrop, RH and Smith, TF (1996). Global optimum protein threading with gapped alignment and empirical pair score functions. Journal of Molecular Biology. 255, 641-665.
24. Das, S, Yu, L, Lindelien, J, Gaitatzes, Ce, Rogers, R, Freeman, J, Bienkowska, J, Adams, M and Smith, TF. (1996). Exploiting biology's new Rosetta Stone. Nature 385, 29-30.
25. Smith, T.F. (1990) The history of the genetic sequence databases. Genomics, 6, 701-707.