Sequences in IG format used in pimaII example.
; LOCUS 1COHA
;
1COHA
VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAV
AHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKY
R1
; LOCUS 2MHBA
;
2MHBA
VLSAADKTNVKAAWSKVGGHAGEYGAEALERMFLGFPTTKTYFPHFDLSHGSAQVKAHGKKVGDALTLAV
GHLDDLPGALSDLSNLHAHKLRVDPVNFKLLSHCLLSTLAVHLPNDFTPAVHASLDKFLSSVSTVLTSKY
R1
; TOIG of: glb5_petma check: 7918 from: 1 to: 149
;
; ID GLB5_PETMA STANDARD; PRT; 149 AA.
; AC P02208;
; DT 21-JUL-1986 (REL. 01, CREATED)
; DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
; DT 01-MAR-1992 (REL. 21, LAST ANNOTATION UPDATE)
; DE GLOBIN V.
; OS PETROMYZON MARINUS (SEA LAMPREY).
; OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; PISCES;
; OC AGNATHA (CYCLOSTOMATA).
; RN [1]
; RP SEQUENCE.
; RX MEDLINE; 83257424.
; RA HOMBRADOS I., RODEWALD K., NEUZIL E., BRAUNITZER G.;
; RL BIOCHIMIE 65:247-257(1983).
; RN [2]
; RP SEQUENCE.
; RX MEDLINE; 71051151.
; RA LI S.L., RIGGS A.;
; RL J. BIOL. CHEM. 245:6149-6169(1970).
; RN [3]
; RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
; RX MEDLINE; 73143809.
; RA HENDRICKSON W.A., LOVE W.E., KARLE J.;
; RL J. MOL. BIOL. 74:331-361(1973).
; RN [4]
; RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
; RX MEDLINE; 85293078.
; RA HONZATKO R.B., HENDRICKSON W.A., LOVE W.E.;
; RL J. MOL. BIOL. 184:147-164(1985).
; CC -!- GLOBIN V IS THE MAJOR COMPONENT OF THE 6 GLOBINS FOUND IN THE SEA
; CC LAMPREY.
; CC -!- SUBUNIT: MONOMER AT HIGH OXYGEN TENSION AND HIGH PH AND DIMERIC
; CC AT LOW OXYGEN TENSION AND LOWER PH.
; DR PIR; A02529; GGLMS.
; DR PDB; 2LHB; 15-APR-91.
; DR PROSITE; PS01033; GLOBIN.
; KW HEME; OXYGEN TRANSPORT; RESPIRATORY PROTEIN; 3D-STRUCTURE.
; FT VARIANT 29 29 T -> N.
; FT CONFLICT 95 95 S -> SS (IN REF. 3).
; FT CONFLICT 98 99 MISSING (IN REF. 2 AND 3).
; FT CONFLICT 100 100 D -> N (IN REF. 2).
; FT CONFLICT 138 138 M -> R (IN REF. 2 AND 3).
; FT CONFLICT 139 139 MISSING (IN REF. 2).
; FT HELIX 13 28
; FT TURN 29 29
; FT HELIX 30 44
; FT HELIX 46 51
; FT HELIX 53 55
; FT TURN 56 57
; FT HELIX 61 65
; FT TURN 66 66
; FT HELIX 68 86
; FT TURN 87 89
; FT HELIX 91 107
; FT TURN 108 108
; FT HELIX 113 128
; FT TURN 129 130
; FT HELIX 132 146
; FT TURN 147 148
; SQ SEQUENCE 149 AA; 16270 MW; 39647AAC CRC32;
;
; GLB5_PETMA Length: 149 April 15, 1997 16:43 Type: P Check: 7918 ..
glb5petma
PIVDTGSVAPLSAAEKTKIRSAWAPVYSTYETSGVDILVKFFTSTPAAQEFFPKFKGLTTADQLKKSADV
RWHAERIINAVNDAVASMDDTEKMSMKLRDLSGKHAKSFQVDPQYFKVLAAVIADTVAAGDAGFEKLMSM
ICILLRSAY1
; TOIG of: hba_horse check: 83 from: 1 to: 141
;
; ID HBA_HORSE STANDARD; PRT; 141 AA.
; AC P01958;
; DT 21-JUL-1986 (REL. 01, CREATED)
; DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
; DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE)
; DE HEMOGLOBIN ALPHA CHAINS (SLOW AND FAST).
; OS EQUUS CABALLUS (HORSE).
; OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
; OC EUTHERIA; PERISSODACTYLA.
; RN [1]
; RP SEQUENCE FROM N.A.
; RX MEDLINE; 85037948.
; RA CLEGG J.B., GOODBOURN S.E.Y., BRAEND M.;
; RL NUCLEIC ACIDS RES. 12:7847-7858(1984).
; RN [2]
; RP SEQUENCE FROM N.A.
; RX MEDLINE; 88216145.
; RA CLEGG J.B.;
; RL MOL. BIOL. EVOL. 4:492-503(1987).
; RN [3]
; RP SEQUENCE.
; RX MEDLINE; 81005583.
; RA MATSUDA G., MAITA T., BRAUNITZER G., SCHRANK B.;
; RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 361:1107-1116(1980).
; RN [4]
; RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
; RX MEDLINE; 76240583.
; RA LADNER R.C., AIR G.M., FOGG J.H.;
; RL J. MOL. BIOL. 103:675-677(1976).
; CC -!- POLYMORPHISM: HORSE HAS TWO NONALLELIC ALPHA CHAINS, SLOW AND
; CC FAST. THE SLOW CHAIN SEQUENCE IS SHOWN.
; DR EMBL; X01086; G1079; -.
; DR EMBL; M17902; G164211; -.
; DR EMBL; X07053; G313500; -.
; DR PIR; A02281; HAHO.
; DR PDB; 2DHB; 30-SEP-83.
; DR PDB; 2MHB; 30-SEP-83.
; DR PROSITE; PS01033; GLOBIN.
; KW HEME; OXYGEN TRANSPORT; RESPIRATORY PROTEIN; ERYTHROCYTE;
; KW POLYMORPHISM; 3D-STRUCTURE.
; FT INIT_MET 0 0
; FT METAL 58 58 IRON (HEME DISTAL LIGAND).
; FT METAL 87 87 IRON (HEME PROXIMAL LIGAND).
; FT VARIANT 24 24 Y -> F (EXIST IN BOTH CHAINS).
; FT VARIANT 60 60 K -> Q (IN FAST CHAIN).
; FT HELIX 4 35
; FT HELIX 37 42
; FT TURN 44 45
; FT TURN 50 51
; FT HELIX 53 70
; FT TURN 71 74
; FT HELIX 76 79
; FT TURN 80 80
; FT HELIX 81 89
; FT TURN 90 90
; FT TURN 95 95
; FT HELIX 96 112
; FT TURN 114 116
; FT HELIX 119 136
; FT TURN 137 140
; SQ SEQUENCE 141 AA; 15114 MW; 32DA1BF8 CRC32;
;
; HBA_HORSE Length: 141 April 15, 1997 15:23 Type: P Check: 83 ..
hbahorse
VLSAADKTNVKAAWSKVGGHAGEYGAEALERMFLGFPTTKTYFPHFDLSHGSAQVKAHGKKVGDALTLAV
GHLDDLPGALSNLSDLHAHKLRVDPVNFKLLSHCLLSTLAVHLPNDFTPAVHASLDKFLSSVSTVLTSKY
R1
; TOIG of: hba_human check: 9231 from: 1 to: 141
;
; ID HBA_HUMAN STANDARD; PRT; 141 AA.
; AC P01922;
; DT 21-JUL-1986 (REL. 01, CREATED)
; DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
; DT 01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE)
; DE HEMOGLOBIN ALPHA CHAIN.
; GN HBA1 AND HBA2.
; OS HOMO SAPIENS (HUMAN), PAN TROGLODYTES (CHIMPANZEE), AND PAN PANISCUS
; OS (PYGMY CHIMPANZEE) (BONOBO).
; OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
; OC EUTHERIA; PRIMATES.
; RN [1]
; RP SEQUENCE FROM N.A. (ALPHA-1).
; RX MEDLINE; 81088339.
; RA MICHELSON A.M., ORKIN S.H.;
; RL CELL 22:371-377(1980).
; RN [2]
; RP SEQUENCE FROM N.A. (ALPHA-2).
; RX MEDLINE; 81175088.
; RA LIEBHABER S.A., GOOSSENS M.J., KAN Y.W.;
; RL PROC. NATL. ACAD. SCI. U.S.A. 77:7054-7058(1980).
; RN [3]
; RP SEQUENCE FROM N.A. (ALPHA-2).
; RX MEDLINE; 80137531.
; RA WILSON J.T., WILSON L.B., REDDY V.B., CAVALLESCO C., GHOSH P.K.,
; RA DERIEL J.K., FORGET B.G., WEISSMAN S.M.;
; RL J. BIOL. CHEM. 255:2807-2815(1980).
; RN [4]
; RP SEQUENCE.
; RA BRAUNITZER G., GEHRING-MULLER R., HILSCHMANN N., HILSE K., HOBOM G.,
; RA RUDLOFF V., WITTMANN-LIEBOLD B.;
; RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 325:283-286(1961).
; RN [5]
; RP SEQUENCE.
; RA HILL R.J., KONIGSBERG W.;
; RL J. BIOL. CHEM. 237:3151-3156(1962).
; RN [6]
; RP SEQUENCE.
; RA SCHROEDER W.A., SHELTON J.R., SHELTON J.B., CORMICK J.;
; RL BIOCHEMISTRY 2:1353-1357(1963).
; RN [7]
; RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF DEOXYHEMOGLOBIN.
; RX MEDLINE; 76027820.
; RA FERMI G.;
; RL J. MOL. BIOL. 97:237-256(1975).
; RN [8]
; RP X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF LIGANDED R2 STATE.
; RX MEDLINE; 92381041.
; RA SILVA M.M., ROGERS P.H., ARNONE A.;
; RL J. BIOL. CHEM. 267:17248-17256(1992).
; RN [9]
; RP SEQUENCE.
; RC SPECIES=P.TROGLODYTES;
; RX MEDLINE; 66071496.
; RA RIFKIN D.B., KONIGSBERG W.;
; RL BIOCHIM. BIOPHYS. ACTA 104:457-461(1965).
; RN [10]
; RP SEQUENCE FROM N.A.
; RC SPECIES=P.TROGLODYTES;
; RX MEDLINE; 84169526.
; RA LIEBHABER S.A., BEGLEY K.A.;
; RL NUCLEIC ACIDS RES. 11:8915-8929(1983).
; RN [11]
; RP SEQUENCE.
; RC SPECIES=P.PANISCUS;
; RX MEDLINE; 83219265.
; RA GOODMAN M., BRAUNITZER G., STANGL A., SCHRANK B.;
; RL NATURE 303:546-548(1983).
; RN [12]
; RP VARIANT AL-AIN ABU DHABI.
; RX MEDLINE; 93053723.
; RA ABBES S., M'RAD A., FITZGERALD P.A., DORMER P., BLOUQUIT Y.,
; RA KISTER J., GALACTEROS F., WAJCMAN H.;
; RL HEMOGLOBIN 16:355-362(1992).
; RN [13]
; RP VARIANT ATAGO.
; RX MEDLINE; 72030550.
; RA FUJIWARA N., MAEKAWA T., MATSUDA G.;
; RL INT. J. PROTEIN RES. 3:35-39(1971).
; RN [14]
; RP VARIANTS J-BUDA AND G-PEST.
; RA BRIMHALL B.J., DUERST M., HOLLAN S.R., STENZEL P., SZELENYI J.,
; RA JONES R.T.;
; RL BIOCHIM. BIOPHYS. ACTA 336:344-360(1974).
; RN [15]
; RP VARIANTS CHONGQING AND HARBIN.
; RX MEDLINE; 85130255.
; RA ZENG Y.-T., HUANG S.-Z., QIU X.-K., CHENG G.-C., REN Z.-R., JIN Q.-C.,
; RA CHEN C.-Y., JIAO C.-T., TANG Z.-G., LIU R.-H., BAO X.-H., ZENG L.-Z.,
; RA DUAN Y.-Q., ZHANG G.-Y.;
; RL HEMOGLOBIN 8:569-581(1984).
; RN [16]
; RP VARIANT DAVENPORT.
; RX MEDLINE; 91331854.
; RA WILSON J.B., WEBBER B.B., PLASESKA D., DE ALARCON P.A., MCMILLAN S.K.,
; RA HUISMAN T.H.;
; RL HEMOGLOBIN 14:599-605(1990).
; RN [17]
; RP VARIANT EVANS.
; RX MEDLINE; 90109650.
; RA WILSON J.B., WEBBER B.B., KUTLAR A., REESE A.L., MCKIE V.C.,
; RA LUTCHER C.L., FELICE A.E., HUISMAN T.H.J.;
; RL HEMOGLOBIN 13:557-566(1989).
; RN [18]
; RP VARIANTS FORT DE FRANCE AND SPANISH TOWN.
; RX MEDLINE; 89323437.
; RA CASH F.E., MONPLAISIR N., GOOSSENS M., LIEBHABER S.A.;
; RL BLOOD 74:833-835(1989).
; RN [19]
; RP VARIANT HANAMAKI.
; RX MEDLINE; 92340291.
; RA ORISAKA M., TAJIMA T., HARANO T., HARANO K., KUSHIDA Y., IMAI K.;
; RL HEMOGLOBIN 16:67-71(1992).
; RN [20]
; RP VARIANT HANDA.
; RX MEDLINE; 83056269.
; RA HARANO T., HARANO K., SHIBATA S., UEDA S., IMAI K., SEKI M.;
; RL HEMOGLOBIN 6:379-389(1982).
; RN [21]
; RP VARIANT HASHARON.
; RX MEDLINE; 69165810.
; RA CHARACHE S., MONDZAC A.M., GESSNER U.;
; RL J. CLIN. INVEST. 48:834-847(1969).
; RN [22]
; RP VARIANT HOBART.
; RX MEDLINE; 88006902.
; RA FLEMING P.J., SUMNER D.R., WYATT K., HUGHES W.G., MELROSE W.D.,
; RA JUPE D.M.D., BAIKIE M.J.;
; RL HEMOGLOBIN 11:211-220(1987).
; RN [23]
; RP VARIANT INKSTER.
; RX MEDLINE; 74302151.
; RA REED R.E., WINTER W.P., RUCKNAGEL D.L.;
; RL BR. J. HAEMATOL. 26:475-484(1974).
; RN [24]
; RP VARIANT KANAGAWA.
; RX MEDLINE; 92340282.
; RA MIYASHITA H., HASHIMOTO K., MOHRI H., OHOKUBO T., HARANO T.,
; RA HARANO K., IMAI K.;
; RL HEMOGLOBIN 16:1-10(1992).
; RN [25]
; RP VARIANT KURDISTAN.
; RX MEDLINE; 94252883.
; RA GIORDANO P.C., HARTEVELD C.L., STRENG H., OOSTERWIJK J.C.,
; RA HEISTER J.G.A.M., AMONS R., BERNINI L.F.;
; RL HEMOGLOBIN 18:11-18(1994).
; RN [26]
; RP VARIANT J-MEERUT OR J-BIRMINGHAM.
; RX MEDLINE; 95229430.
; RA YALCIN A., AVCU F., BEYAN C., GUERGEY A., URAL A.U.;
; RL HEMOGLOBIN 18:433-435(1994).
; RN [27]
; RP VARIANT MELUSINE.
; RX MEDLINE; 94124250.
; RA WACJMAN H., KLAMES G., GROFF P., PROME D., RIOU J., GALACTEROS F.;
; RL HEMOGLOBIN 17:397-405(1993).
; RN [28]
; RP VARIANT MONTGOMERY.
; RX MEDLINE; 75109326.
; RA BRIMHALL B., JONES R.T., SCHNEIDER R.G., HOSTY T.S., TOMLIN G.,
; RA ATKINS R.;
; RL BIOCHIM. BIOPHYS. ACTA 379:28-32(1975).
; RN [29]
; RP VARIANT PETAH TIKVA.
; RX MEDLINE; 81134478.
; RA HONIG G.R., SHAMSUDDIN M., ZAIZOV R., STEINHERZ M., SOLAR I.,
; RA KIRSCHMAN C.;
; RL BLOOD 57:705-711(1981).
; RN [30]
; RP VARIANT PORT HURON.
; RX MEDLINE; 92202056.
; RA ZWERDLING T., WILLIAMS S., NASR S.A., RUCKNAGEL D.L.;
; RL HEMOGLOBIN 15:381-391(1991).
; RN [31]
; RP VARIANT SAWARA.
; RX MEDLINE; 74008827.
; RA SUMIDA I., OHTA Y., IMAMURA T., YANASE T.;
; RL BIOCHIM. BIOPHYS. ACTA 322:23-26(1973).
; RN [32]
; RP VARIANT SHENYANG.
; RX MEDLINE; 83135048.
; RA ZENG Y.-T., HUANG S.-Z., ZHOU X., QIU X.-K., DONG Q., LI M., BAI J.;
; RL HEMOGLOBIN 6:625-628(1982).
; RN [33]
; RP VARIANT SUAN-DOK.
; RX MEDLINE; 80006169.
; RA SANGUANSERMSRI T., MATRAGOON S., CHANGLOAH L., FLATZ G.;
; RL HEMOGLOBIN 3:161-174(1979).
; RN [34]
; RP VARIANT SUN PRAIRIE.
; RX MEDLINE; 91177710.
; RA HARKNESS M., HARKNESS D.R., KUTLAR F., KUTLAR A., WILSON J.B.,
; RA WEBBER B.B., CODRINGTON J.F., HUISMAN T.H.J.;
; RL HEMOGLOBIN 14:479-489(1990).
; RN [35]
; RP VARIANT THIONVILLE.
; RX MEDLINE; 92316953.
; RA VASSEUR C., BLOUQUIT Y., KISTER J., PROME D., KAVANAUGH J.S.,
; RA ROGERS P.H., GUILLEMIN C., ARNONE A., GALACTEROS F., POYART C.,
; RA ROSA J., WAJCMAN H.;
; RL J. BIOL. CHEM. 267:12682-12691(1992).
; RN [36]
; RP VARIANT TUNIS-BIZERTE.
; RX MEDLINE; 95306384.
; RA DARBELLAY R., MACH-PASCUAL S., ROSE K., GRAF J., BERIS P.;
; RL BR. J. HAEMATOL. 90:71-76(1995).
; RN [37]
; RP VARIANT TURRIFF.
; RX MEDLINE; 92340284.
; RA LANGDOWN J.V., DAVIDSON R.J., WILLIAMSON D.;
; RL HEMOGLOBIN 16:11-17(1992).
; RN [38]
; RP VARIANT VAL DE MARNE.
; RX MEDLINE; 94124251.
; RA WACJMAN H., KISTER J., M'RAD A., MARDEN M.C., RIOU J., GALACTEROS F.;
; RL HEMOGLOBIN 17:407-417(1993).
; RN [39]
; RP VARIANT WESTMEAD.
; RX MEDLINE; 92155975.
; RA JIANG N.H., LIANG S., WEN X.J., LIANG R., SU C., TANG Z.;
; RL HEMOGLOBIN 15:291-295(1991).
; RN [40]
; RP VARIANT WOODVILLE.
; RX MEDLINE; 86167529.
; RA COMO P.F., BARBER S., SAGE R.E., KRONENBERG H.;
; RL HEMOGLOBIN 10:135-141(1986).
; RN [41]
; RP VARIANT YUDA.
; RX MEDLINE; 93053734.
; RA FUJISAWA K., HATTORI Y., OHBA Y., ANDO S.;
; RL HEMOGLOBIN 16:435-439(1992).
; CC -!- SUBUNIT: ALPHA CHAINS BUILD EARLY EMBRYONIC HEMOGLOBIN GOWER-2
; CC (WITH EPSILON CHAINS), FETAL HEMOGLOBIN F (WITH GAMMA CHAINS), AND
; CC ADULT HEMOGLOBIN A (WITH BETA CHAINS).
; CC -!- THE CHIMPANZEE AND PYGMY CHIMPANZEE SEQUENCES ARE IDENTICAL WITH
; CC THAT OF HUMAN.
; CC -!- POLYMORPHISM: A COMPLETE LIST OF HUMAN GLOBIN VARIANTS IS
; CC PUBLISHED ONCE A YEAR IN THE JOURNAL HEMOGLOBIN. WE HAVE INDICATED
; CC HERE A FEW WELL KNOWN VARIANTS.
; CC -!- DISEASE: SOME RARE FORMS OF ALPHA-THALASSAEMIA ARE DUE TO POINT
; CC MUTATIONS (NON-DELETIONAL ALPHA-THALASSAEMIA). THE THALLASSAEMIC
; CC PHENOTYPE IS DUE TO UNSTABLE GLOBIN ALPHA CHAINS THAT ARE RAPIDLY
; CC CATABOLIZED PRIOR TO FORMATION OF THE ALPHA-BETA DIMERS.
; DR EMBL; J00153; G386764; -.
; DR EMBL; J00153; G386765; -.
; DR EMBL; V00488; G28547; -.
; DR EMBL; V00491; E74447; -.
; DR EMBL; V00493; G28558; -.
; DR EMBL; X00226; G38223; -.
; DR EMBL; X00227; G38225; -.
; DR PIR; A02248; HAHU.
; DR PIR; A93303; HACZ.
; DR PIR; C93303; HACZP.
; DR PDB; 1COH; 15-OCT-94.
; DR PDB; 1FDH; 30-SEP-83.
; DR PDB; 1HBS; 29-OCT-85.
; DR PDB; 1HCO; 30-SEP-83.
; DR PDB; 2HCO; 30-SEP-83.
; DR PDB; 1HHO; 31-JAN-84.
; DR PDB; 2HHB; 15-OCT-89.
; DR PDB; 3HHB; 18-JUL-84.
; DR PDB; 4HHB; 15-OCT-89.
; DR PDB; 1THB; 15-JAN-91.
; DR PDB; 1NIH; 15-OCT-92.
; DR PDB; 1BAB; 31-JAN-94.
; DR PDB; 1BBB; 31-JAN-94.
; DR PDB; 1CMY; 31-OCT-93.
; DR PDB; 1DXT; 31-OCT-93.
; DR PDB; 1DXU; 31-OCT-93.
; DR PDB; 1DXV; 31-OCT-93.
; DR PDB; 1HBA; 31-JAN-94.
; DR PDB; 1HBB; 31-JAN-94.
; DR PDB; 1HGA; 31-JAN-94.
; DR PDB; 1HGB; 31-JAN-94.
; DR PDB; 1HGC; 31-JAN-94.
; DR SWISS-2DPAGE; P01922; HUMAN.
; DR MIM; 141800; -.
; DR MIM; 141850; -.
; DR MIM; 141860; -.
; DR PROSITE; PS01033; GLOBIN.
; KW HEME; OXYGEN TRANSPORT; RESPIRATORY PROTEIN; ERYTHROCYTE;
; KW DISEASE MUTATION; POLYMORPHISM; ACETYLATION; 3D-STRUCTURE.
; FT INIT_MET 0 0
; FT METAL 58 58 IRON (HEME DISTAL LIGAND).
; FT METAL 87 87 IRON (HEME PROXIMAL LIGAND).
; FT MOD_RES 0 0 ACETYLATION (IN VARIANT THIONVILLE; WHERE
; FT THE INITIATOR MET IS NOT CLEAVED).
; FT VARIANT 1 1 V -> E (IN THIONVILLE; O2 AFFINITY DOWN).
; FT VARIANT 2 2 L -> R (IN CHONGQING; O2 AFFINITY UP).
; FT VARIANT 5 5 A -> D (IN J-TORONTO).
; FT VARIANT 5 5 A -> P (IN KARACHI).
; FT VARIANT 6 6 D -> A (IN SAWARA; O2 AFFINITY UP).
; FT VARIANT 6 6 D -> N (IN DUNN; O2 AFFINITY UP).
; FT VARIANT 6 6 D -> V (IN FERNDOWN; O2 AFFINITY UP).
; FT VARIANT 6 6 D -> Y (IN WOODVILLE; O2 AFFINITY UP).
; FT VARIANT 11 11 K -> E (IN ANANTHARAJ).
; FT VARIANT 12 12 A -> D (IN J-PARIS 1/J-ALJEZUR).
; FT VARIANT 14 14 W -> R (IN EVANSTON; O2 AFFINITY UP).
; FT VARIANT 15 15 G -> R (IN OTTAWA/SIAM).
; FT VARIANT 16 16 K -> M (IN HARBIN; SLIGHTLY UNSTABLE).
; FT VARIANT 16 16 K -> N (IN BEIJING).
; FT VARIANT 18 18 G -> D (IN AL-AIN-ABU DHABI).
; FT VARIANT 18 18 G -> R (IN HANDSWORTH).
; FT VARIANT 19 19 A -> D (IN J-KUROSH).
; FT VARIANT 19 19 A -> E (IN TASHIKUERGAN).
; FT VARIANT 20 20 H -> Q (IN LE LAMENTIN).
; FT VARIANT 20 20 H -> R (IN HOBART).
; FT VARIANT 21 21 A -> D (IN J-NYANZA).
; FT VARIANT 21 21 A -> P (IN FONTAINEBLAU).
; FT VARIANT 22 22 G -> D (IN J-MEDELLIN).
; FT VARIANT 23 23 E -> G (IN REIMS; SLIGHTLY UNSTABLE).
; FT VARIANT 23 23 E -> K (IN CHAD).
; FT VARIANT 24 24 Y -> H (IN LUXEMBOURG; UNSTABLE).
; FT VARIANT 26 26 A -> E (IN SHENYANG; UNSTABLE).
; FT VARIANT 27 27 E -> D (IN HEKINAN).
; FT VARIANT 27 27 E -> G (IN FORT WORTH).
; FT VARIANT 27 27 E -> V (IN SPANISH TOWN).
; FT VARIANT 30 30 E -> K (IN O-PADOVA).
; FT VARIANT 31 31 R -> S (IN PRATO; UNSTABLE).
; FT VARIANT 34 34 L -> R (IN QUEENS/OGI).
; FT VARIANT 37 37 P -> R (IN BOURMEDES).
; FT VARIANT 40 40 K -> M (IN KANAGAWA; O2 AFFINITY UP).
; FT VARIANT 41 41 T -> S (IN MIYANO; O2 AFFINITY UP).
; FT VARIANT 43 43 F -> L (IN HIROSAKI; UNSTABLE).
; FT VARIANT 44 44 P -> L (IN MILLEDGEVILLE; O2 AFFINITY
; FT UP).
; FT VARIANT 44 44 P -> R (IN KAWACHI; O2 AFFINITY UP).
; FT VARIANT 45 45 H -> Q (IN BARI).
; FT VARIANT 45 45 H -> R (IN FORT DE FRANCE; O2 AFFINITY
; FT UP).
; FT VARIANT 47 47 D -> A (IN CORDELE; UNSTABLE).
; FT VARIANT 47 47 D -> G (IN UMI/MICHIGAN; UNSTABLE).
; FT VARIANT 47 47 D -> H (IN HASHARON/SINAI; UNSTABLE).
; FT VARIANT 47 47 D -> Y (IN KURDISTAN).
; FT VARIANT 48 48 L -> R (IN MONTGOMERY).
; FT VARIANT 49 49 S -> R (IN SAVARIA).
; FT VARIANT 50 50 H -> R (IN AICHI; SLIGHTLY UNSTABLE).
; FT VARIANT 51 51 G -> D (IN J-ABIDJAN).
; FT VARIANT 51 51 G -> R (IN RUSS).
; FT VARIANT 53 53 A -> D (IN J-ROVIGO; UNSTABLE).
; FT VARIANT 54 54 Q -> R (IN HIKOSHIMA/SHIMONOSEKI).
; FT VARIANT 56 56 K -> R (IN PORT HURON).
; FT VARIANT 56 56 K -> T (IN THAILAND).
; FT VARIANT 57 57 G -> R (IN L-PERSIAN GULF).
; FT VARIANT 58 58 H -> Y (IN M-BOSTON/M-OSAKA; O2 AFFINITY
; FT DOWN).
; FT VARIANT 59 59 G -> D (IN ADANA; UNSTABLE;
; FT CAUSES ALPHA-THALASSAEMIA).
; FT VARIANT 59 59 G -> V (IN TOTTORI; UNSTABLE).
; FT VARIANT 60 60 K -> N (IN ZAMBIA).
; FT VARIANT 61 61 K -> N (IN J-BUDA).
; FT VARIANT 61 61 K -> T (IN J-ANATOLIA).
; FT VARIANT 62 62 V -> M (IN EVANS; UNSTABLE).
; FT VARIANT 63 63 A -> D (IN PONTOISE; UNSTABLE).
; FT VARIANT 64 64 D -> Y (IN PERSEPOLIS).
; FT VARIANT 68 68 N -> K (IN G-PHILADELPHIA).
; FT VARIANT 71 71 A -> E (IN J-HABANA).
; FT VARIANT 71 71 A -> V (IN OZIERI).
; FT VARIANT 72 72 H -> R (IN DANESHGAH-TEHERAN).
; FT VARIANT 74 74 D -> A (IN LILLE).
; FT VARIANT 74 74 D -> G (IN CHAPEL HILL).
; FT VARIANT 74 74 D -> N (IN G-PEST).
; FT VARIANT 75 75 D -> A (IN DUAN).
; FT VARIANT 75 75 D -> H (IN Q-IRAN).
; FT VARIANT 76 76 M -> K (IN NOKO).
; FT VARIANT 76 76 M -> T (IN AZTEC).
; FT VARIANT 77 77 P -> R (IN GUIZHOU).
; FT VARIANT 78 78 N -> H (IN DAVENPORT).
; FT VARIANT 78 78 N -> K (IN STANLEYVILLE-2).
; FT VARIANT 80 80 L -> R (IN ANN ARBOR; UNSTABLE).
; FT VARIANT 81 81 S -> C (IN NIGERIA).
; FT VARIANT 82 82 A -> D (IN GARDEN STATE).
; FT VARIANT 84 84 S -> R (IN ETOBICOKE; O2 AFFINITY UP).
; FT VARIANT 85 85 D -> V (IN INKSTER; O2 AFFINITY UP).
; FT VARIANT 85 85 D -> Y (IN ATAGO; O2 AFFINITY UP).
; FT VARIANT 86 86 L -> R (IN MOABIT; UNSTABLE).
; FT VARIANT 87 87 H -> R (IN IWATA; UNSTABLE).
; FT VARIANT 88 88 A -> S (IN LOIRE; O2 AFFINITY UP).
; FT VARIANT 90 90 K -> M (IN HANDA; O2 AFFINITY UP).
; FT VARIANT 91 91 L -> P (IN PORT PHILLIP; UNSTABLE).
; FT VARIANT 92 92 R -> Q (IN J-CAPE TOWN; O2 AFFINITY UP).
; FT VARIANT 94 94 D -> Y (IN SETIF; UNSTABLE).
; FT VARIANT 95 95 P -> A (IN DENMARK HILL; O2 AFFINITY UP).
; FT VARIANT 97 97 N -> K (IN DALLAS; O2 AFFINITY UP).
; FT VARIANT 99 99 K -> E (IN TURRIFF).
; FT VARIANT 102 102 S -> R (IN MANITOBA; SLIGHTLY UNSTABLE).
; FT VARIANT 103 103 H -> R (IN CONTALDO; UNSTABLE).
; FT VARIANT 109 109 L -> R (IN SUAN-DOK; UNSTABLE;
; FT CAUSES ALPHA-THALASSAEMIA).
; FT VARIANT 110 110 A -> D (IN PETAH TIKVA; UNSTABLE;
; FT CAUSES ALPHA-THALASSAEMIA).
; FT VARIANT 112 112 H -> D (IN HOPKINS-II; UNSTABLE).
; FT VARIANT 113 113 L -> H (IN TWIN PEAKS).
; FT VARIANT 114 114 P -> L (IN NOUAKCHOTT).
; FT VARIANT 114 114 P -> R (IN CHIAPAS).
; FT VARIANT 114 114 P -> S (IN MELUSINE).
; FT VARIANT 115 115 A -> D (IN J-TONGARIKI).
; FT VARIANT 116 116 E -> A (IN UBE-4).
; FT VARIANT 120 120 A -> E (IN J-MEERUT/J-BIRMINGHAM).
; FT VARIANT 121 121 V -> M (IN OWARI).
; FT VARIANT 122 122 H -> Q (IN WESTMEAD).
; FT VARIANT 125 125 L -> P (IN QUONG SZE;
; FT CAUSES ALPHA-THALASSAEMIA).
; FT VARIANT 126 126 D -> V (IN FUKUTOMI; O2 AFFINITY UP).
; FT VARIANT 126 126 D -> Y (IN MONTERIORE; O2 AFFINITY UP).
; FT VARIANT 127 127 K -> N (IN JACKSON).
; FT VARIANT 129 129 L -> P (IN TUNIS-BIZERTE; UNSTABLE;
; FT CAUSES ALPHA-THALASSAEMIA).
; FT VARIANT 130 130 A -> P (IN SUN PRAIRIE; UNSTABLE).
; FT VARIANT 130 130 A -> D (IN YUDA; O2 AFFINITY DOWN).
; FT VARIANT 131 131 S -> P (IN QUESTEMBERT; HIGHLY UNSTABLE;
; FT CAUSES ALPHA-THALASSAEMIA).
; FT VARIANT 133 133 S -> R (IN VAL DE MARNE; O2 AFFINITY UP).
; FT VARIANT 135 135 V -> E (IN PAVIE).
; FT VARIANT 136 136 L -> M (IN CHICAGO).
; FT VARIANT 136 136 L -> P (IN BIBBA; UNSTABLE;
; FT CAUSES ALPHA-THALASSAEMIA).
; FT VARIANT 138 138 S -> P (IN ATTLEBORO; O2 AFFINITY UP).
; FT VARIANT 139 139 K -> E (IN HANAKAMI; O2 AFFINITY UP).
; FT VARIANT 139 139 K -> T (IN TOKONAME; O2 AFFINITY UP).
; FT VARIANT 140 140 Y -> H (IN ROUEN; O2 AFFINITY UP).
; FT VARIANT 141 141 R -> C (IN NUNOBIKI; O2 AFFINITY UP).
; FT VARIANT 141 141 R -> L (IN LEGNANO; O2 AFFINITY UP).
; FT VARIANT 141 141 R -> H (IN SURESNES; O2 AFFINITY UP).
; FT VARIANT 141 141 R -> P (IN SINGAPORE).
; FT HELIX 4 35
; FT HELIX 37 42
; FT TURN 44 45
; FT TURN 50 51
; FT HELIX 53 71
; FT TURN 72 74
; FT HELIX 76 79
; FT TURN 80 80
; FT HELIX 81 89
; FT TURN 90 91
; FT TURN 95 95
; FT HELIX 96 112
; FT TURN 114 116
; FT HELIX 119 136
; FT TURN 137 139
; SQ SEQUENCE 141 AA; 15126 MW; 5EC7DB1E CRC32;
;
; HBA_HUMAN Length: 141 April 15, 1997 16:42 Type: P Check: 9231 ..
hbahuman
VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAV
AHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKY
R1
; TOIG of: hbb_horse check: 1311 from: 1 to: 146
;
; ID HBB_HORSE STANDARD; PRT; 146 AA.
; AC P02062;
; DT 21-JUL-1986 (REL. 01, CREATED)
; DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
; DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
; DE HEMOGLOBIN BETA CHAIN.
; OS EQUUS CABALLUS (HORSE).
; OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
; OC EUTHERIA; PERISSODACTYLA.
; RN [1]
; RP SEQUENCE.
; RX MEDLINE; 81005583.
; RA MATSUDA G., MAITA T., BRAUNITZER G., SCHRANK B.;
; RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 361:1107-1116(1980).
; RN [2]
; RP SEQUENCE OF 1-82 AND 117-146.
; RX MEDLINE; 68397920.
; RA SMITH D.B.;
; RL CAN. J. BIOCHEM. 46:825-843(1968).
; RN [3]
; RP DETERMINATION OF AMIDES, AND SEQUENCE OF 52-54.
; RX MEDLINE; 71027939.
; RA SMITH D.B., CHUNG W.P.;
; RL CAN. J. BIOCHEM. 48:1160-1164(1970).
; RN [4]
; RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
; RX MEDLINE; 78007980.
; RA LADNER R.C., HEIDNER E.J., PERUTZ M.F.;
; RL J. MOL. BIOL. 114:385-414(1977).
; DR PIR; A02380; HBHO.
; DR PDB; 2DHB; 30-SEP-83.
; DR PDB; 2MHB; 30-SEP-83.
; DR PROSITE; PS01033; GLOBIN.
; KW HEME; OXYGEN TRANSPORT; RESPIRATORY PROTEIN; ERYTHROCYTE;
; KW 3D-STRUCTURE.
; FT METAL 63 63 IRON (HEME DISTAL LIGAND).
; FT METAL 92 92 IRON (HEME PROXIMAL LIGAND).
; FT HELIX 5 15
; FT TURN 16 17
; FT HELIX 20 34
; FT HELIX 36 45
; FT HELIX 51 55
; FT TURN 56 56
; FT HELIX 58 75
; FT TURN 76 77
; FT HELIX 78 84
; FT HELIX 86 93
; FT TURN 94 95
; FT TURN 100 100
; FT HELIX 101 121
; FT HELIX 124 142
; SQ SEQUENCE 146 AA; 16008 MW; C2AE3F68 CRC32;
;
; HBB_HORSE Length: 146 April 15, 1997 16:42 Type: P Check: 1311 ..
hbbhorse
VQLSGEEKAAVLALWDKVNEEEVGGEALGRLLVVYPWTQRFFDSFGDLSNPGAVMGNPKVKAHGKKVLHS
FGEGVHHLDNLKGTFAALSELHCDKLHVDPENFRLLGNVLVVVLARHFGKDFTPELQASYQKVVAGVANA
LAHKYH1
; TOIG of: hbb_human check: 1242 from: 1 to: 146
;
; ID HBB_HUMAN STANDARD; PRT; 146 AA.
; AC P02023;
; DT 21-JUL-1986 (REL. 01, CREATED)
; DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
; DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE)
; DE HEMOGLOBIN BETA CHAIN.
; GN HBB.
; OS HOMO SAPIENS (HUMAN), PAN TROGLODYTES (CHIMPANZEE), AND PAN PANISCUS
; OS (PYGMY CHIMPANZEE) (BONOBO).
; OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
; OC EUTHERIA; PRIMATES.
; RN [1]
; RP SEQUENCE.
; RC SPECIES=HUMAN;
; RA BRAUNITZER G., GEHRING-MULLER R., HILSCHMANN N., HILSE K., HOBOM G.,
; RA RUDLOFF V., WITTMANN-LIEBOLD B.;
; RL HOPPE-SEYLER'S Z. PHYSIOL. CHEM. 325:283-286(1961).
; RN [2]
; RP SEQUENCE FROM N.A.
; RC SPECIES=HUMAN;
; RX MEDLINE; 81064667.
; RA LAWN R.M., EFSTRATIADIS A., O'CONNELL C., MANIATIS T.;
; RL CELL 21:647-651(1980).
; RN [3]
; RP SEQUENCE OF 121-146 FROM N.A.
; RC SPECIES=HUMAN;
; RX MEDLINE; 85205333.
; RA LANG K.M., SPRITZ R.A.;
; RL GENE 33:191-196(1985).
; RN [4]
; RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF DEOXYHEMOGLOBIN.
; RC SPECIES=HUMAN;
; RX MEDLINE; 76027820.
; RA FERMI G.;
; RL J. MOL. BIOL. 97:237-256(1975).
; RN [5]
; RP SEQUENCE.
; RC SPECIES=P.TROGLODYTES;
; RX MEDLINE; 66071496.
; RA RIFKIN D.B., KONIGSBERG W.;
; RL BIOCHIM. BIOPHYS. ACTA 104:457-461(1965).
; RN [6]
; RP SEQUENCE.
; RC SPECIES=P.PANISCUS;
; RX MEDLINE; 83219265.
; RA GOODMAN M., BRAUNITZER G., STANGL A., SCHRANK B.;
; RL NATURE 303:546-548(1983).
; RN [7]
; RP HAPTOGLOBIN BINDING.
; RX MEDLINE; 86242088.
; RA YOSHIOKA N., ATASSI M.Z.;
; RL BIOCHEM. J. 234:453-456(1986).
; RN [8]
; RP VARIANT ALABAMA.
; RX MEDLINE; 75109326.
; RA BRIMHALL B., JONES R.T., SCHNEIDER R.G., HOSTY T.S., TOMLIN G.,
; RA ATKINS R.;
; RL BIOCHIM. BIOPHYS. ACTA 379:28-32(1975).
; RN [9]
; RP VARIANT ALESHA.
; RX MEDLINE; 93322192.
; RA MOLCHANOVA T.P., POSTNIKOV Y.V., POBEDIMSKAYA D.D., SMETANINA N.S.,
; RA MOSCHAN A.A., KAZANETZ E.G., TOKAREV Y.N., HUISMAN T.H.J.;
; RL HEMOGLOBIN 17:217-225(1993).
; RN [10]
; RP VARIANT J-ALTGELDS GARDENS.
; RX MEDLINE; 79067354.
; RA ADAMS J.G. III, PRZYWARA K.P., HELLER P., SHAMSUDDIN M.;
; RL HEMOGLOBIN 2:403-415(1978).
; RN [11]
; RP VARIANT ANKARAS.
; RX MEDLINE; 74297498.
; RA ARCASOY A., CASEY R., LEHMANN H., CAVDAR A.O., BERKI A.;
; RL FEBS LETT. 42:121-123(1974).
; RN [12]
; RP VARIANTS J-ANTAKYA AND COMPLUTENSE.
; RX MEDLINE; 86216227.
; RA HUISMAN T.H.J., WILSON J.B., KUTLAR A., YANG K.-G., CHEN S.-S.,
; RA WEBBER B.B., ALTAY C., MARTINEZ A.V.;
; RL BIOCHIM. BIOPHYS. ACTA 871:229-231(1986).
; RN [13]
; RP VARIANT J-AUCKLAND.
; RX MEDLINE; 88006903.
; RA WILLIAMSON D., WELLS R.M.G., ANDERSON R., MATTHEWS J.;
; RL HEMOGLOBIN 11:221-230(1987).
; RN [14]
; RP VARIANT BREST.
; RX MEDLINE; 88256755.
; RA BAUDIN-CHICH V., WAJCMAN H., GOMBAUD-SAINTONGE G., AROUS N., RIOU J.,
; RA BRIERE J., GALACTEROS F.;
; RL HEMOGLOBIN 12:179-188(1988).
; RN [15]
; RP VARIANT BRISBANE.
; RX MEDLINE; 81239159.
; RA BRENNAN S.O., WELLS R.M., SMITH H., CARRELL R.W.;
; RL HEMOGLOBIN 5:325-335(1981).
; RN [16]
; RP VARIANT BUNBURY.
; RX MEDLINE; 84031649.
; RA COMO P.F., KENNETT D., WILKINSON T., KRONENBERG H.;
; RL HEMOGLOBIN 7:413-421(1983).
; RN [17]
; RP VARIANT J-CAIRO.
; RX MEDLINE; 76114933.
; RA GAREL M.-C., HASSAN W., COQUELET M.T., GOOSSENS M., ROSA J., AROUS N.;
; RL BIOCHIM. BIOPHYS. ACTA 420:97-104(1976).
; RN [18]
; RP VARIANT CARIBBEAN.
; RX MEDLINE; 77048866.
; RA AHERN E., AHERN V., HILTON T., SERJEANT G.R., SERJEANT B.E.,
; RA SEAKINS M., LANG A., MIDDLETON A., LEHMANN H.;
; RL FEBS LETT. 69:99-102(1976).
; RN [19]
; RP VARIANT CITY OF HOPE.
; RX MEDLINE; 85006311.
; RA RAHBAR S., ASMEROM Y., BLUME K.G.;
; RL HEMOGLOBIN 8:333-342(1984).
; RN [20]
; RP VARIANT COIMBRA.
; RX MEDLINE; 92267852.
; RA TAMAGNINI G.P., RIBEIRO M.L., VALENTE V., RAMACHANDRAN M.,
; RA WILSON J.B., BAYSAL E., GU L.H., HUISMAN T.H.J.;
; RL HEMOGLOBIN 15:487-496(1991).
; RN [21]
; RP VARIANT COSTA RICA.
; RX MEDLINE; 96235282.
; RA ROMERO W.E.R., CASTILLO M., CHAVES M.A., SAENZ G.F., GU L.-H.,
; RA WILSON J.B., BAYSAL E., SMETANINA N.S., LEONOVA J.Y., HUISMAN T.H.J.;
; RL HUM. GENET. 97:829-833(1996).
; RN [22]
; RP VARIANT DHONBURI.
; RX MEDLINE; 90379198.
; RA BARDAKDJIAN-MICHAU J., FUCHAROEN S., DELANOE-GARIN J., KISTER J.,
; RA LACOMBE C., WINICHAGOON P., BLOUQUIT Y., RIOU J., WASI P.,
; RA GALACTEROS F.;
; RL AM. J. HEMATOL. 35:96-99(1990).
; RN [23]
; RP VARIANT GEELONG.
; RX MEDLINE; 92010939.
; RA COMO P.F., HOCKING D.R., SWINTON G.W., TRENT R.J., HOLLAND R.A.,
; RA TIBBEN E.A., WILKINSON T., KRONENBERG H.;
; RL HEMOGLOBIN 15:85-95(1991).
; RN [24]
; RP VARIANT GRANGE-BLANCHE.
; RX MEDLINE; 88030044.
; RA BAKLOUTI F., GIRAUD Y., FRANCINA A., RICHARD G., PERIER C.,
; RA GEYSSANT A., JAUBERT J., BRIZARD C., DELAUNAY J.;
; RL FEBS LETT. 223:59-62(1987).
; RN [25]
; RP VARIANT GRAZ.
; RX MEDLINE; 93138927.
; RA LIU J.S., MOLCHANOVA T.P., GU L.H., WILSON J.B., HOPMEIER P.,
; RA SCHNEDL W., BALAUN E., KREJS G.J., HUISMAN T.H.J.;
; RL HEMOGLOBIN 16:493-501(1992).
; RN [26]
; RP VARIANT HELSINKI.
; RX MEDLINE; 77062201.
; RA IKKALA E., KOSKELA J., PIKKARAINEN P., RAHIALA E.-L., EL-HAZMI M.A.F.,
; RA NAGAI K., LANG A., LEHMANN H.;
; RL ACTA HAEMATOL. 56:257-275(1976).
; RN [27]
; RP VARIANT HIMEJI.
; RX MEDLINE; 86167527.
; RA OHBA Y., MIYAJI T., MURAKAMI M., KADOWAKI S., FUJITA T., OIMOMI M.,
; RA HATANAKA H., ISHIKAWA K., BABA S., HITAKA K., IMAI K.;
; RL HEMOGLOBIN 10:109-126(1986).
; RN [28]
; RP VARIANT HINSDALE.
; RX MEDLINE; 90093866.
; RA MOO-PENN W.F., JOHNSON M.H., JUE D.L., LONSER R.;
; RL HEMOGLOBIN 13:455-464(1989).
; RN [29]
; RP VARIANT HOWICK.
; RX MEDLINE; 94193408.
; RA OWEN M.C., OCKELFORD P.A., WELLS R.M.G.;
; RL HEMOGLOBIN 17:513-521(1993).
; RN [30]
; RP VARIANT INDIANAPOLIS.
; RX MEDLINE; 79151109.
; RA ADAMS J.G. III, STEINBERG M.H., BOXER L.A., BAEHNER R.L., FORGET B.G.,
; RA TSISTRAKIS G.A.;
; RL J. BIOL. CHEM. 254:3479-3482(1979).
; RN [31]
; RP VARIANT ISEHARA.
; RX MEDLINE; 92155974.
; RA HARANO T., HARANO K., KUSHIDA Y., UEDA S., YOSHII A., NISHINARITA M.;
; RL HEMOGLOBIN 15:279-290(1991).
; RN [32]
; RP VARIANT ISTAMBUL.
; RX MEDLINE; 73054825.
; RA AKSOY M., ERDEM S., EFREMOV G.D., WILSON J.B., HUISMAN T.H.J.,
; RA SCHROEDER W.A., SHELTON J.R., SHELTON J.B., ULITIN O.N.,
; RA MUFTUOGLU A.;
; RL J. CLIN. INVEST. 51:2380-2387(1972).
; RN [33]
; RP VARIANT JACKSONVILLE.
; RX MEDLINE; 91331861.
; RA GAUDRY C.L. JR., PITEL P.A., JUE D.L., HINE T.K., JOHNSON M.H.,
; RA MOO-PENN W.F.;
; RL HEMOGLOBIN 14:653-659(1990).
; RN [34]
; RP VARIANT JIANGHUA.
; RX MEDLINE; 84007581.
; RA LU Y.Q., FAN J.L., LIU J.F., HU H.L., PENG X.H., HUANG C.H.,
; RA HUANG P.Y., CHEN S.S., JAI P.C., YANG K.G.;
; RL HEMOGLOBIN 7:321-326(1983).
; RN [35]
; RP VARIANT KARLSKOGA.
; RX MEDLINE; 93322190.
; RA LANDIN B.;
; RL HEMOGLOBIN 17:201-208(1993).
; RN [36]
; RP VARIANT KNOSSOS.
; RX MEDLINE; 83079719.
; RA AROUS N., GALACTEROS F., FESSAS P., LOUKOPOULOS D., BLOUQUIT Y.,
; RA KOMIS G., SELLAYE M., BOUSSIOU M., ROSA J.;
; RL FEBS LETT. 147:247-250(1982).
; RN [37]
; RP VARIANT KODAIRA.
; RX MEDLINE; 92340295.
; RA HARANO T., HARANO K., KUSHIDA Y., IMAI K., NISHINAKAMURA R.,
; RA MATSUNAGA T.;
; RL HEMOGLOBIN 16:85-91(1992).
; RN [38]
; RP VARIANT KOFU.
; RX MEDLINE; 86303641.
; RA HARANO T., HARANO K., UEDA S., IMAI N., KITAZUMI T.;
; RL HEMOGLOBIN 10:417-420(1986).
; RN [39]
; RP VARIANT KRALOVE.
; RX MEDLINE; 94042221.
; RA DIVOKY V., SVOBODOVA M., INDRAK K., CHROBAK L., MOLCHANOVA T.P.,
; RA HUISMAN T.H.J.;
; RL HEMOGLOBIN 17:319-328(1993).
; RN [40]
; RP VARIANT LA DESIRADE.
; RX MEDLINE; 87165149.
; RA MERAULT G., KECLARD L., GARIN J., POYART C., BLOUQUIT Y., AROUS N.,
; RA GALACTEROS F., FEINGOLD J., ROSA J.;
; RL HEMOGLOBIN 10:593-605(1986).
; RN [41]
; RP VARIANT LAS PALMAS.
; RX MEDLINE; 88256753.
; RA MALCORRA-AZPIAZU J.J., BALDA-AGUIRRE M.I., DIAZ-CHICO J.C., HU H.,
; RA WILSON J.B., WEBBER B.B., KUTLAR F., KUTLAR A., HUISMAN T.H.J.;
; RL HEMOGLOBIN 12:163-170(1988).
; RN [42]
; RP VARIANT LINKOEPING.
; RX MEDLINE; 88083482.
; RA BERLIN G., WRANNE B., JEPPSSON J.-O.;
; RL EUR. J. HAEMATOL. 39:452-456(1987).
; RN [43]
; RP VARIANT MAPUTO.
; RX MEDLINE; 84031650.
; RA MARINUCCI M., BOISSEL J.P., MASSA A., WAJCMAN H., TENTORI L.,
; RA LABIE D.;
; RL HEMOGLOBIN 7:423-433(1983).
; RN [44]
; RP VARIANT MATERA.
; RX MEDLINE; 90346586.
; RA SCIARRATTA G.V., IVALDI G.;
; RL HEMOGLOBIN 14:79-85(1990).
; RN [45]
; RP VARIANT MIYASHIRO.
; RX MEDLINE; 82166873.
; RA NAKATSUJI T., MIWA S., OHBA Y., HATTORI Y., MIYAJI T., MIYATA H.,
; RA SHINOHARA T., HORI T., TAKAYAMA J.;
; RL HEMOGLOBIN 5:653-666(1981).
; RN [46]
; RP VARIANT MIZUHO.
; RX MEDLINE; 77248961.
; RA OHBA Y., MIYAJI T., MATSUOKA M., SUGIYAMA K., SUZUKI T., SUGIURA T.;
; RL HEMOGLOBIN 1:467-477(1977).
; RN [47]
; RP VARIANT MUSCAT.
; RX MEDLINE; 92387956.
; RA RAMACHANDRAN M., GU L.H., WILSON J.B., KITUNDU M.N., ADEKILE A.D.,
; RA LIU J.C., MCKIE K.M., HUISMAN T.H.;
; RL HEMOGLOBIN 16:259-266(1992).
; RN [48]
; RP VARIANT N-TIMONE.
; RX MEDLINE; 90236754.
; RA LENA-RUSSO D., ORSINI A., VOVAN L., BARDAKDJIAN-MICHAU J., LACOMBE C.,
; RA BLOUQUIT Y., CRAESCU C.T., GALACTEROS F.;
; RL HEMOGLOBIN 13:743-747(1989).
; RN [49]
; RP VARIANT NAGOYA.
; RX MEDLINE; 85206960.
; RA OHBA Y., IMANAKA M., MATSUOKA M., HATTORI Y., MIYAJI T., FUNAKI C.,
; RA SHIBATA K., SHIMOKATA H., KUZUYA F., MIWA S.;
; RL HEMOGLOBIN 9:11-24(1985).
; RN [50]
; RP VARIANT D-NEATH.
; RX MEDLINE; 93322197.
; RA WELCH S.G., BATEMAN C.;
; RL HEMOGLOBIN 17:255-259(1993).
; RN [51]
; RP VARIANT NORTH CHICAGO.
; RX MEDLINE; 86139289.
; RA RAHBAR S., LOUIS J., LEE T., ASMEROM Y.;
; RL HEMOGLOBIN 9:559-576(1985).
; RN [52]
; RP VARIANT NORTH SHORE.
; RX MEDLINE; 77246803.
; RA ARENDS T., LEHMANN H., PLOWMAN D., STATHOPOULOU R.;
; RL FEBS LETT. 80:261-265(1977).
; RN [53]
; RP VARIANT OLOMOUC.
; RX MEDLINE; 87307470.
; RA INDRAK K., WIEDERMANN B.F., BATEK F., WILSON J.B., WEBBER B.B.,
; RA KUTLAR A., HUISMAN T.H.J.;
; RL HEMOGLOBIN 11:151-155(1987).
; RN [54]
; RP VARIANT PALMERSTON NORTH.
; RX MEDLINE; 83135041.
; RA BRENNAN S.O., WILLIAMSON D., WHISSON M.E., CARRELL R.W.;
; RL HEMOGLOBIN 6:569-575(1982).
; RN [55]
; RP VARIANT PIERRE-BENITE.
; RX MEDLINE; 88256754.
; RA BAKLOUTI F., GIRAUD Y., FRANCINA A., RICHARD G., FAVRE-GILLY J.,
; RA DELAUNAY J.;
; RL HEMOGLOBIN 12:171-177(1988).
; RN [56]
; RP VARIANT PRESBYTERIAN.
; RX MEDLINE; 78215075.
; RA MOO-PENN W.F., WOLFF J.A., SIMON G., VACEK M., JUE D.L., JOHNSON M.H.;
; RL FEBS LETT. 92:53-56(1978).
; RN [57]
; RP VARIANT PUTTELANGE.
; RX MEDLINE; 96101899.
; RA WAJCMAN H., GIRODON E., PROME D., NORTH M.L., PLASSA F., DUWIG I.,
; RA KISTER J., BERGERAT J.P., OBERLING F., LAMPERT E., LONSDORFER J.,
; RA GOOSSENS M., GALACTEROS F.;
; RL HUM. GENET. 96:711-716(1995).
; RN [58]
; RP VARIANT QUIN-HAI.
; RX MEDLINE; 84031648.
; RA JEN P.C., CHEN L.C., CHEN P.F., WONG Y., CHEN L.F., GUO Y.Y.,
; RA CHANG F.Q., CHOW Y.C., CHIU Y.;
; RL HEMOGLOBIN 7:407-412(1983).
; RN [59]
; RP VARIANT RANDWICK.
; RX MEDLINE; 88256752.
; RA GILBERT A.T., FLEMING P.J., SUMNER D.R., HUGHES W.G., IP F.,
; RA KWAN Y.L., HOLLAND R.A.;
; RL HEMOGLOBIN 12:149-161(1988).
; RN [60]
; RP VARIANT RIO GRANDE.
; RX MEDLINE; 83185445.
; RA MOO-PENN W.F., JOHNSON M.H., MCGUFFEY J.E., JUE D.L.,
; RA THERRELL B.L. JR.;
; RL HEMOGLOBIN 7:91-95(1983).
; RN [61]
; RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF VARIANT ROTSCHILD.
; RX MEDLINE; 92232710.
; RA KAVANAUGH J.S., ROGERS P.H., CASE D.A., ARNONE A.;
; RL BIOCHEMISTRY 31:4111-4121(1992).
; RN [62]
; RP VARIANT RUSH.
; RX MEDLINE; 74080282.
; RA ADAMS J.G. III, WINTER W.P., TAUSK K., HELLER P.;
; RL BLOOD 43:261-269(1974).
; RN [63]
; RP VARIANT SAITAMA.
; RX MEDLINE; 83185440.
; RA OHBA Y., HASEGAWA Y., AMINO H., MIWA S., NAKATSUJI T., HATTORI Y.,
; RA MIYAJI T.;
; RL HEMOGLOBIN 7:47-56(1983).
; RN [64]
; RP VARIANT M-SASKATOON.
; RA GERALD P.S., EFRON M.L.;
; RL PROC. NATL. ACAD. SCI. U.S.A. 47:1758-1767(1961).
; RN [65]
; RP VARIANT SHELBY.
; RX MEDLINE; 85130256.
; RA MOO-PENN W.F., JOHNSON M.H., MCGUFFEY J.E., JUE D.L.;
; RL HEMOGLOBIN 8:583-593(1984).
; RN [66]
; RP VARIANT J-SICILIA.
; RX MEDLINE; 74302182.
; RA RICCO G., PICH P.G., MAZZA U., ROSSI G., AJMAR P., ARESE P., GALLO E.;
; RL FEBS LETT. 39:200-204(1974).
; RN [67]
; RP VARIANT STANMORE.
; RX MEDLINE; 92010936.
; RA COMO P.F., WYLIE B.R., TRENT R.J., BRUCE D., VOLPATO F., WILKINSON T.,
; RA KRONENBERG H., HOLLAND R.A., TIBBEN E.A.;
; RL HEMOGLOBIN 15:53-65(1991).
; RN [68]
; RP VARIANT ST MANDE.
; RX MEDLINE; 81212764.
; RA AROUS N., BRACONNIER F., THILLET J., BLOUQUIT Y., GALACTEROS F.,
; RA CHEVRIER M., BORDAHANDY C., ROSA J.;
; RL FEBS LETT. 126:114-116(1981).
; RN [69]
; RP VARIANT WINDSOR.
; RX MEDLINE; 90093865.
; RA GILBERT A.T., FLEMING P.J., SUMNER D.R., HUGHES W.G., HOLLAND R.A.,
; RA TIBBEN E.A.;
; RL HEMOGLOBIN 13:437-453(1989).
; RN [70]
; RP VARIANT YAHATA.
; RX MEDLINE; 92010926.
; RA HARANO T., HARANO K., KUSHIDA Y., UEDA S.;
; RL HEMOGLOBIN 15:109-113(1991).
; RN [71]
; RP VARIANT YOKOHAMA.
; RX MEDLINE; 82166874.
; RA NAKATSUJI T., MIWA S., OHBA Y., HATTORI Y., MIYAJI T., HINO S.,
; RA MATSUMOTO N.;
; RL HEMOGLOBIN 5:667-678(1981).
; CC -!- THE HUMAN SEQUENCE IS SHOWN. THE CHIMPANZEE AND PYGMY CHIMPANZEE
; CC SEQUENCE APPEARS TO BE IDENTICAL.
; CC -!- POLYMORPHISM: A COMPLETE LIST OF HUMAN GLOBIN VARIANTS IS
; CC PUBLISHED ONCE A YEAR IN THE JOURNAL HEMOGLOBIN.
; CC -!- DISEASE: DEFICIENCY IN BETA-GLOBIN IS THE CAUSE OF SICKLE CELL
; CC ANEMIA AND POLYCYTHEMIA.
; DR EMBL; U01317; G455997; -.
; DR EMBL; V00497; G29437; -.
; DR EMBL; V00499; G29441; -.
; DR EMBL; V00500; G29446; ALT_SEQ.
; DR EMBL; L26462; G532506; -.
; DR EMBL; L26463; G532507; -.
; DR EMBL; L26464; G532514; -.
; DR EMBL; L26465; G532508; -.
; DR EMBL; L26466; G532509; -.
; DR EMBL; L26467; G532510; -.
; DR EMBL; L26468; G532511; -.
; DR EMBL; L26469; G532512; -.
; DR EMBL; L26470; G532513; -.
; DR EMBL; L26471; G532515; -.
; DR EMBL; L26472; G532516; -.
; DR EMBL; L26473; G532517; -.
; DR EMBL; L26474; G532518; -.
; DR EMBL; L26475; G532519; -.
; DR EMBL; L26476; G532520; -.
; DR EMBL; L26477; G532521; -.
; DR EMBL; L26478; G532522; -.
; DR EMBL; L48213; G1066768; -.
; DR EMBL; L48214; G1066771; -.
; DR EMBL; L48215; G1066774; -.
; DR EMBL; L48216; G1066777; -.
; DR EMBL; L48217; G1066780; -.
; DR EMBL; M36640; G183830; -.
; DR EMBL; M11428; G386766; -.
; DR EMBL; A01592; G344422; -.
; DR PIR; A02352; HBHU.
; DR PIR; B93303; HBCZ.
; DR PIR; D93303; HBCZP.
; DR PDB; 1CBL; 31-JUL-94.
; DR PDB; 1CBM; 31-JUL-94.
; DR PDB; 1COH; 15-OCT-94.
; DR PDB; 1HBS; 29-OCT-85.
; DR PDB; 1HCO; 30-SEP-83.
; DR PDB; 2HCO; 30-SEP-83.
; DR PDB; 1HHO; 31-JAN-84.
; DR PDB; 2HHB; 18-JUL-84.
; DR PDB; 3HHB; 18-JUL-84.
; DR PDB; 4HHB; 17-JUL-84.
; DR PDB; 1THB; 15-JAN-91.
; DR PDB; 1NIH; 15-OCT-92.
; DR PDB; 1BAB; 31-JAN-94.
; DR PDB; 1BBB; 31-JAN-94.
; DR PDB; 1CMY; 31-OCT-93.
; DR PDB; 1DXT; 31-OCT-93.
; DR PDB; 1DXU; 31-OCT-93.
; DR PDB; 1DXV; 31-OCT-93.
; DR PDB; 1HBA; 31-JAN-94.
; DR PDB; 1HBB; 31-JAN-94.
; DR PDB; 1HGA; 31-JAN-94.
; DR PDB; 1HGB; 31-JAN-94.
; DR PDB; 1HGC; 31-JAN-94.
; DR SWISS-2DPAGE; P02023; HUMAN.
; DR HSC-2DPAGE; P02023; HUMAN.
; DR MIM; 141900; -.
; DR PROSITE; PS01033; GLOBIN.
; KW HEME; OXYGEN TRANSPORT; RESPIRATORY PROTEIN; ERYTHROCYTE;
; KW DISEASE MUTATION; POLYMORPHISM; 3D-STRUCTURE.
; FT INIT_MET 0 0
; FT METAL 63 63 IRON (HEME DISTAL LIGAND).
; FT METAL 92 92 IRON (HEME PROXIMAL LIGAND).
; FT MOD_RES 1 1 ACETYLATION (IN VARIANT RALEIGH).
; FT VARIANT 1 1 V -> A (IN RALEIGH; O2 AFFINITY DOWN).
; FT VARIANT 2 2 H -> L (IN GRAZ).
; FT VARIANT 2 2 H -> Q (IN OKAYAMA; O2 AFFINITY UP).
; FT VARIANT 2 2 H -> R (IN DEER LODGE; O2 AFFINITY UP).
; FT VARIANT 2 2 H -> Y (IN FUKUOKA).
; FT VARIANT 5 5 P -> R (IN WARWICKSHIRE).
; FT VARIANT 6 6 E -> A (IN G-MAKASSAR).
; FT VARIANT 6 6 E -> V (IN S; SICKLE CELL ANEMIA).
; FT VARIANT 6 6 E -> K (IN C).
; FT VARIANT 6 6 E -> Q (IN MACHIDA).
; FT VARIANT 7 7 E -> G (IN G-SAN JOSE; MILDLY UNSTABLE).
; FT VARIANT 7 7 E -> K (IN SIRIRAJ).
; FT VARIANT 8 8 K -> E (IN N-TIMONE).
; FT VARIANT 8 8 K -> Q (IN J-LUHE).
; FT VARIANT 8 8 K -> T (IN RIO GRANDE).
; FT VARIANT 9 9 S -> C (IN PORTO ALEGRE; O2 AFFINITY UP).
; FT VARIANT 10 10 A -> D (IN ANKARA).
; FT VARIANT 11 11 V -> D (IN WINDSOR; O2 AFFINITY UP;
; FT UNSTABLE).
; FT VARIANT 11 11 V -> I (IN HAMILTON).
; FT VARIANT 13 13 A -> D (IN J-LENS).
; FT VARIANT 14 14 L -> P (IN SAKI; UNSTABLE).
; FT VARIANT 14 14 L -> R (IN SOEGN; UNSTABLE).
; FT VARIANT 15 15 W -> G (IN RANDWICK; UNSTABLE).
; FT VARIANT 15 15 W -> R (IN BELFAST; O2 AFFINITY UP;
; FT UNSTABLE).
; FT VARIANT 16 16 G -> D (IN J-BALTIMORE/J-TRINIDAD/
; FT J-IRELAND/J-GEORGIA/N-NEW HAVEN).
; FT VARIANT 16 16 G -> R (IN D-BUSHMAN).
; FT VARIANT 17 17 K -> E (IN NAGASAKI).
; FT VARIANT 17 17 K -> N (IN J-AMIENS).
; FT VARIANT 17 17 K -> Q (IN NIKOSIA).
; FT VARIANT 18 18 V -> M (IN BADEN; SLIGHTLY INSTABLE).
; FT VARIANT 19 19 N -> D (IN ALAMO).
; FT VARIANT 19 19 N -> K (IN D-OULEH RABAH).
; FT VARIANT 19 19 N -> S (IN MALAY).
; FT VARIANT 20 20 V -> M (IN OLYMPIA; O2 AFFINITY UP).
; FT VARIANT 21 21 D -> G (IN CONNECTICUT; O2 AFFINITY
; FT DOWN).
; FT VARIANT 21 21 D -> N (IN COCODY).
; FT VARIANT 21 21 D -> H (IN KARLSKOGA).
; FT VARIANT 21 21 D -> Y (IN YUSA).
; FT VARIANT 22 22 E -> A (IN G-COUSHATTA/G-SASKATOON/
; FT G-TAEGU/HSIN CHU).
; FT VARIANT 22 22 E -> G (IN G-TAIPEI).
; FT VARIANT 22 22 E -> K (IN E-SASKATOON; UNSTABLE).
; FT VARIANT 22 22 E -> Q (IN D-IRAN).
; FT VARIANT 22 22 E -> V (IN D-GRANADA).
; FT VARIANT 23 23 V -> D (IN STRASBOURG; O2 AFFINITY UP).
; FT VARIANT 23 23 V -> F (IN PALMERSTON NORTH; O2 AFFINITY
; FT UP; UNSTABLE).
; FT VARIANT 23 23 V -> G (IN MIYASHIRO; O2 AFFINITY UP;
; FT UNSTABLE).
; FT VARIANT 24 24 G -> D (IN MOSCVA; O2 AFFINITY DOWN;
; FT UNSTABLE).
; FT VARIANT 24 24 G -> R (IN RIVERDALE-BRONX; O2 AFFINITY
; FT UP; UNSTABLE).
; FT VARIANT 24 24 G -> V (IN SAVANNAH; UNSTABLE).
; FT VARIANT 25 25 G -> D (IN J-AUCKLAND; UNSTABLE; O2
; FT AFFINITY DOWN).
; FT VARIANT 25 25 G -> R (IN G-TAIWAN AMI).
; FT VARIANT 26 26 E -> K (IN E).
; FT VARIANT 26 26 E -> V (IN HENRI MONDOR; SLIGHTLY
; FT UNSTABLE).
; FT VARIANT 27 27 A -> D (IN VOLGA/DRENTHE; UNSTABLE).
; FT VARIANT 27 27 A -> S (IN KNOSSOS).
; FT VARIANT 27 27 A -> V (IN GRANGE-BLANCHE; O2 AFFINITY
; FT UP).
; FT VARIANT 28 28 L -> P (IN GENOVA/HYOGO; UNSTABLE).
; FT VARIANT 29 29 G -> D (IN LUFKIN; UNSTABLE).
; FT VARIANT 30 30 R -> S (IN TACOMA; UNSTABLE).
; FT VARIANT 31 31 L -> P (IN YOKOHAMA; UNSTABLE).
; FT VARIANT 32 32 L -> R (IN CASTILLA; UNSTABLE).
; FT VARIANT 32 32 L -> V (IN MUSCAT; SLIGHTLY UNSTABLE).
; FT VARIANT 34 34 V -> F (IN PITIE-SALPETRIERE; O2 AFFINITY
; FT UP).
; FT VARIANT 35 35 Y -> F (IN PHILLY; O2 AFFINITY UP;
; FT UNSTABLE).
; FT VARIANT 36 36 P -> R (IN SUNNYBROOK).
; FT VARIANT 36 36 P -> S (IN NORTH CHICAGO; O2 AFFINITY
; FT UP).
; FT VARIANT 36 36 P -> T (IN LINKOEPING/FINLANDIA; O2
; FT AFFINITY UP).
; FT VARIANT 37 37 W -> G (IN HOWICK).
; FT VARIANT 37 37 W -> S (IN HIROSE; O2 AFFINITY UP).
; FT VARIANT 37 37 W -> R (IN ROTHSCHILD; O2 AFFINITY DOWN).
; FT VARIANT 39 39 Q -> E (IN VAASA; UNSTABLE).
; FT VARIANT 39 39 Q -> K (IN ALABAMA).
; FT VARIANT 39 39 Q -> R (IN TIANSHUI).
; FT VARIANT 41 41 F -> Y (IN MEQUON).
; FT VARIANT 42 42 F -> L (IN LOUISVILLE; UNSTABLE).
; FT VARIANT 43 43 E -> Q (IN HOSHIDA/CHAYA).
; FT VARIANT 44 44 S -> C (IN MISSISSIPPI).
; FT VARIANT 45 45 F -> S (IN CHEVERLY; UNSTABLE).
; FT VARIANT 46 46 G -> E (IN K-IBADAN).
; FT VARIANT 47 47 D -> A (IN AVICENNA).
; FT VARIANT 47 47 D -> G (IN GAVELLO).
; FT VARIANT 47 47 D -> Y (IN MAPUTO).
; FT VARIANT 48 48 L -> P (IN BAB-SAADOUN; SLIGHLTY
; FT UNSTABLE).
; FT VARIANT 49 49 S -> F (IN LAS PALMAS; SLIGHTLY
; FT UNSTABLE).
; FT VARIANT 50 50 T -> K (IN EDMONTON).
; FT VARIANT 51 51 P -> R (IN WILLAMETTE; O2 AFFINITY UP;
; FT UNSTABLE).
; FT VARIANT 52 52 D -> A (IN OCHO RIOS).
; FT VARIANT 52 52 D -> H (IN SUMMER HILL).
; FT VARIANT 54 54 V -> D (IN JACKSONVILLE; O2 AFFINITY UP;
; FT UNSTABLE).
; FT VARIANT 55 55 M -> K (IN MATERA; UNSTABLE).
; FT VARIANT 56 56 G -> R (IN HAMADAN).
; FT VARIANT 57 57 N -> K (IN G-FERRARA; UNSTABLE).
; FT VARIANT 58 58 P -> R (IN DHOFAR/YUKUHASHI).
; FT VARIANT 59 59 K -> E (IN I-HIGH WYCOMBE).
; FT VARIANT 60 60 V -> A (IN COLLINGWOOD; UNSTABLE).
; FT VARIANT 61 61 K -> E (IN N-SEATLLE).
; FT VARIANT 61 61 K -> M (IN BOLOGNA; O2 AFFINITY DOWN).
; FT VARIANT 61 61 K -> N (IN HIKARI).
; FT VARIANT 62 62 A -> P (IN DUARTE; UNSTABLE).
; FT VARIANT 63 63 H -> Y (IN M-SASKATOON; O2 AFFINITY UP).
; FT VARIANT 65 65 K -> M (IN J-ANTAKYA).
; FT VARIANT 65 65 K -> N (IN J-SICILIA).
; FT VARIANT 65 65 K -> Q (IN J-CAIRO).
; FT VARIANT 66 66 K -> T (IN CHICO; O2 AFFINITY DOWN).
; FT VARIANT 67 67 V -> A (IN SIDNEY; UNSTABLE).
; FT VARIANT 67 67 V -> M (IN ALESHA; UNSTABLE).
; FT VARIANT 68 68 L -> H (IN BRISBANE; O2 AFFINITY UP).
; FT VARIANT 68 68 L -> P (IN MIZUHO; UNSTABLE).
; FT VARIANT 69 69 G -> R (IN KENITRA).
; FT VARIANT 69 69 G -> S (IN CITY OF HOPE).
; FT VARIANT 70 70 A -> D (IN SEATTLE; O2 AFFINITY DOWN;
; FT UNSTABLE).
; FT VARIANT 71 71 F -> S (IN CHRISTCHURCH; UNSTABLE).
; FT VARIANT 73 73 D -> G (IN TILBURG; O2 AFFINITY DOWN).
; FT VARIANT 73 73 D -> V (IN MOBILE; O2 AFFINITY DOWN).
; FT VARIANT 73 73 D -> Y (IN VANCOUVER; O2 AFFINITY DOWN).
; FT VARIANT 74 74 G -> R (IN AALBORG; UNSTABLE).
; FT VARIANT 74 74 G -> V (IN BUSHWICK; UNSTABLE).
; FT VARIANT 75 75 L -> P (IN ATLANTA; UNSTABLE).
; FT VARIANT 75 75 L -> R (IN PASADENA; O2 AFFINITY UP;
; FT UNSTABLE).
; FT VARIANT 76 76 A -> D (IN J-CHICAGO).
; FT VARIANT 77 77 H -> D (IN J-IRAN).
; FT VARIANT 77 77 H -> R (IN COSTA RICA).
; FT VARIANT 77 77 H -> Y (IN FUKUYAMA).
; FT VARIANT 78 78 L -> R (IN QUIN-HAI).
; FT VARIANT 79 79 D -> Y (IN TAMPA).
; FT VARIANT 80 80 N -> K (IN G-SZUHU/GIFU).
; FT VARIANT 81 81 L -> R (IN BAYLOR; UNSTABLE).
; FT VARIANT 82 82 K -> M (IN HELSINKI; O2 AFFINITY UP).
; FT VARIANT 83 83 G -> R (IN MUSKEGON).
; FT VARIANT 84 84 T -> I (IN KOFU).
; FT VARIANT 86 86 A -> D (IN OLOMOUC; O2 AFFINITY UP).
; FT VARIANT 87 87 T -> I (IN QUEBEC-CHORI).
; FT VARIANT 87 87 T -> K (IN D-IBADAN).
; FT VARIANT 87 87 T -> P (IN VALLETTA).
; FT VARIANT 88 88 L -> P (IN SANTA ANA; UNSTABLE).
; FT VARIANT 88 88 L -> R (IN BORAS; UNSTABLE).
; FT VARIANT 89 89 S -> N (IN CRETEIL; O2 AFFINITY UP).
; FT VARIANT 89 89 S -> R (IN VANDERBILT; O2 AFFINITY UP).
; FT VARIANT 90 90 E -> D (IN PIERRE-BENITE; O2 AFFINITY
; FT UP).
; FT VARIANT 90 90 E -> K (IN AGENOGI; O2 AFFINITY DOWN).
; FT VARIANT 91 91 L -> P (IN SABINE; UNSTABLE).
; FT VARIANT 91 91 L -> R (IN CARIBBEAN; O2 AFFINITY DOWN;
; FT UNSTABLE).
; FT VARIANT 92 92 H -> D (IN J-ALTGELDS GARDENS; UNSTABLE).
; FT VARIANT 92 92 H -> N (IN ISEHARA; UNSTABLE).
; FT VARIANT 92 92 H -> P (IN NEWCASTLE; UNSTABLE).
; FT VARIANT 92 92 H -> Q (IN ISTAMBUL; O2 AFFINITY UP;
; FT UNSTABLE).
; FT VARIANT 93 93 C -> R (IN OKAZAKI; O2 AFFINITY UP;
; FT UNSTABLE).
; FT VARIANT 94 94 D -> G (IN CHANDIGARH).
; FT VARIANT 94 94 D -> H (IN BARCELONA; O2 AFFINITY UP).
; FT VARIANT 94 94 D -> N (IN BUNBURY; O2 AFFINITY UP).
; FT VARIANT 95 95 K -> M (IN J-CORDOBA).
; FT VARIANT 95 95 K -> N (IN DETROIT).
; FT VARIANT 96 96 L -> V (IN REGINA; O2 AFFINITY UP).
; FT VARIANT 97 97 H -> L (IN WOOD; O2 AFFINITY UP).
; FT VARIANT 97 97 H -> P (IN NAGOYA; O2 AFFINITY UP;
; FT UNSTABLE).
; FT VARIANT 97 97 H -> Q (IN MALMOE; O2 AFFINITY UP).
; FT VARIANT 97 97 H -> Y (IN MORIGUCHI).
; FT VARIANT 98 98 V -> G (IN NOTTINGHAM; UNSTABLE).
; FT VARIANT 99 99 D -> E (IN COIMBRA; O2 AFFINITY UP).
; FT VARIANT 100 100 P -> L (IN BRIGHAM; O2 AFFINITY UP).
; FT VARIANT 100 100 P -> R (IN NEW MEXICO).
; FT VARIANT 101 101 E -> D (IN POTOMAC; O2 AFFINITY UP).
; FT VARIANT 101 101 E -> G (IN ALBERTA; O2 AFFINITY UP).
; FT VARIANT 101 101 E -> K (IN BRITISH COLUMBIA; O2 AFFINITY
; FT UP).
; FT VARIANT 101 101 E -> Q (IN RUSH; UNSTABLE).
; FT VARIANT 102 102 N -> S (IN BETH ISRAEL; O2 AFFINITY DOWN;
; FT UNSTABLE).
; FT VARIANT 102 102 N -> Y (IN ST MANDE; O2 AFFINITY DOWN).
; FT VARIANT 103 103 F -> L (IN HEATHROW; O2 AFFINITY UP).
; FT VARIANT 104 104 R -> T (IN SHERWOOD FOREST).
; FT VARIANT 107 107 G -> R (IN BURKE; O2 AFFINITY DOWN;
; FT UNSTABLE).
; FT VARIANT 108 108 N -> K (IN PRESBYTERIAN; O2 AFFINITY
; FT DOWN; UNSTABLE).
; FT VARIANT 109 109 V -> M (IN SAN DIEGO; O2 AFFINITY UP).
; FT VARIANT 110 110 L -> P (IN SHOWA-YAKUSHIJI).
; FT VARIANT 111 111 V -> A (IN STANMORE; O2 AFFINITY DOWN;
; FT UNSTABLE).
; FT VARIANT 112 112 C -> R (IN INDIANAPOLIS).
; FT VARIANT 112 112 C -> Y (IN YAHATA).
; FT VARIANT 115 115 A -> D (IN KRALOVE; UNSTABLE; CAUSES
; FT SEVERE BETA-THALASSEMIA).
; FT VARIANT 115 115 A -> P (IN MADRID; UNSTABLE).
; FT VARIANT 116 116 H -> Q (IN HAFNIA).
; FT VARIANT 117 117 H -> P (IN SAITAMA; UNSTABLE).
; FT VARIANT 117 117 H -> R (IN P-GALVESTON).
; FT VARIANT 119 119 G -> A (IN IOWA).
; FT VARIANT 120 120 K -> E (IN HIJIYAMA).
; FT VARIANT 120 120 K -> I (IN JIANGHUA).
; FT VARIANT 120 120 K -> Q (IN TAKAMATSU).
; FT VARIANT 121 121 E -> A (IN D-NEATH).
; FT VARIANT 121 121 E -> G (IN ST FRANCIS).
; FT VARIANT 121 121 E -> Q (IN D-LOS ANGELES/D-PUNJAB/
; FT D-PORTUGAL/D-CHICAGO/D-OAK RIDGE).
; FT VARIANT 121 121 E -> K (IN O-ARAB).
; FT VARIANT 121 121 E -> V (IN D-CAMPERDOWN/BEOGRAD).
; FT VARIANT 123 123 T -> I (IN VILLEJUIF).
; FT VARIANT 124 124 P -> R (IN KHARTOUM; UNSTABLE).
; FT VARIANT 124 124 P -> Q (IN TY GARD; O2 AFFINITY UP).
; FT VARIANT 124 124 P -> S (IN TUNIS).
; FT VARIANT 126 126 V -> A (IN BEIRUT).
; FT VARIANT 126 126 V -> G (IN DHONBURI/NEAPOLIS; UNSTABLE;
; FT BETA-THALASSEMIA).
; FT VARIANT 126 126 V -> E (IN HOFU; UNSTABLE).
; FT VARIANT 127 127 Q -> E (IN COMPLUTENSE).
; FT VARIANT 127 127 Q -> K (IN BREST; UNSTABLE).
; FT VARIANT 128 128 A -> D (IN J-GUANTANAMO; UNSTABLE).
; FT VARIANT 129 129 A -> P (IN CRETE; O2 AFFINITY UP;
; FT UNSTABLE).
; FT VARIANT 129 129 A -> V (IN LA DESIRADE; O2 AFFINITY
; FT DOWN; UNSTABLE).
; FT VARIANT 130 130 Y -> D (IN WIEN; UNSTABLE).
; FT VARIANT 130 130 Y -> S (IN NEVERS).
; FT VARIANT 131 131 Q -> E (IN CAMDEN/TOKUCHI/MOTOWN).
; FT VARIANT 131 131 Q -> K (IN SHELBY/LESLIE/DEACONESS;
; FT UNSTABLE).
; FT VARIANT 131 131 Q -> P (IN SHANGAI; UNSTABLE).
; FT VARIANT 131 131 Q -> R (IN SARREBOURG; UNSTABLE).
; FT VARIANT 132 132 K -> N (IN YAMAGATA; O2 AFFINITY DOWN).
; FT VARIANT 132 132 K -> Q (IN K-WOOLWICH).
; FT VARIANT 133 133 V -> L (IN EXTREDEMURA).
; FT VARIANT 134 134 V -> E (IN NORTH SHORE; UNSTABLE).
; FT VARIANT 135 135 A -> E (IN BECKMAN; O2 AFFINITY DOWN;
; FT UNSTABLE).
; FT VARIANT 135 135 A -> P (IN ALTDORF; O2 AFFINITY UP;
; FT UNSTABLE).
; FT VARIANT 136 136 G -> D (IN HOPE; O2 AFFINITY DOWN;
; FT UNSTABLE).
; FT VARIANT 138 138 A -> P (IN BROCKTON; UNSTABLE).
; FT VARIANT 139 139 N -> D (IN GEELONG; UNSTABLE).
; FT VARIANT 139 139 N -> K (IN HINSDALE; O2 AFFINITY DOWN).
; FT VARIANT 140 140 A -> D (IN HIMEJI; UNSTABLE; O2 AFFINITY
; FT DOWN).
; FT VARIANT 140 140 A -> T (IN ST JACQUES: O2 AFFINITY UP).
; FT VARIANT 140 140 A -> V (IN PUTTELANGE; POLYCYTHEMIA;
; FT O2 AFFINITY UP).
; FT VARIANT 141 141 L -> R (IN OLMSTED; UNSTABLE).
; FT VARIANT 142 142 A -> D (IN OHIO; O2 AFFINITY UP).
; FT VARIANT 143 143 H -> D (IN RANCHO MIRAGE).
; FT VARIANT 143 143 H -> Q (IN LITTLE ROCK; O2 AFFINITY UP).
; FT VARIANT 143 143 H -> P (IN SYRACUSE; O2 AFFINITY UP).
; FT VARIANT 143 143 H -> R (IN ABRUZZO; O2 AFFINITY UP).
; FT VARIANT 144 144 K -> E (IN MITO; O2 AFFINITY UP).
; FT VARIANT 145 145 Y -> C (IN RAINIER; O2 AFFINITY UP).
; FT VARIANT 145 145 Y -> H (IN BETHESDA; O2 AFFINITY UP).
; FT VARIANT 146 146 H -> D (IN HIROSHIMA; O2 AFFINITY UP).
; FT VARIANT 146 146 H -> L (IN COWTOWN; O2 AFFINITY UP).
; FT VARIANT 146 146 H -> P (IN YORK; O2 AFFINITY UP).
; FT VARIANT 146 146 H -> Q (IN KODAIRA; O2 AFFINITY UP).
; FT HELIX 5 15
; FT TURN 16 17
; FT HELIX 20 34
; FT HELIX 36 41
; FT HELIX 43 45
; FT HELIX 51 55
; FT TURN 56 56
; FT HELIX 58 75
; FT TURN 76 77
; FT HELIX 78 94
; FT TURN 95 96
; FT TURN 100 100
; FT HELIX 101 121
; FT HELIX 124 142
; FT TURN 143 144
; SQ SEQUENCE 146 AA; 15867 MW; EC9744C9 CRC32;
;
; HBB_HUMAN Length: 146 April 15, 1997 16:42 Type: P Check: 1242 ..
hbbhuman
VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGA
FSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANA
LAHKYH1
; TOIG of: lgb2_luplu check: 8272 from: 1 to: 153
;
; ID LGB2_LUPLU STANDARD; PRT; 153 AA.
; AC P02240;
; DT 21-JUL-1986 (REL. 01, CREATED)
; DT 01-NOV-1988 (REL. 09, LAST SEQUENCE UPDATE)
; DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE)
; DE LEGHEMOGLOBIN II.
; OS LUPINUS LUTEUS (YELLOW LUPINE).
; OC EUKARYOTA; PLANTA; EMBRYOPHYTA; ANGIOSPERMAE; DICOTYLEDONEAE; FABALES;
; OC FABACEAE.
; RN [1]
; RP SEQUENCE.
; RA EGOROV T.A., KAZAKOV V.K., SHAKHPARONOV M.I., FEIGINA M.Y.,
; RA KOSTETSKY P.V.;
; RL BIOORG. KHIM. 4:476-480(1978).
; RN [2]
; RP SEQUENCE OF 61-153 FROM N.A.
; RX MEDLINE; 87315070.
; RA KONIECZNY A., JENSEN E.O., MARCKER K.A., LEGOCKI A.B.;
; RL MOL. BIOL. REP. 12:61-66(1987).
; RN [3]
; RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
; RA ARUTIUNIAN E.G., KURANOVA I.P., VAINSHTEIN B.K., STEIGEMANN W.;
; RL SOV. PHYS. CRYSTALLOGR. 25:43(1980).
; RN [4]
; RP X-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS).
; RX MEDLINE; 75118996.
; RA VAINSHTEIN B.K., HARUTYUNYAN E.H., KURANOVA I.P., BORISOV V.V.,
; RA SOSFENOV N.I., PAVLOVSKY A.G., GREBENKO A.I., KONAREVA N.V.;
; RL NATURE 254:163-164(1975).
; CC -!- FUNCTION: LEGHEMOGLOBINS ARE HEMOPROTEINS PRESENT IN THE ROOT
; CC NODULES OF LEGUMINOUS PLANTS. THEIR FUNCTION IS TO PROVIDE OXYGEN
; CC TO THE BACTEROIDS, THEY ARE ESSENTIAL FOR SYMBIOTIC NITROGEN
; CC FIXATION.
; CC -!- SUBUNIT: MONOMER.
; DR EMBL; M17893; G168326; -.
; DR PIR; A02562; GPYL2.
; DR PDB; 1LH1; 30-SEP-83.
; DR PDB; 2LH1; 30-SEP-83.
; DR PDB; 1LH2; 30-SEP-83.
; DR PDB; 2LH2; 30-SEP-83.
; DR PDB; 1LH3; 30-SEP-83.
; DR PDB; 2LH3; 30-SEP-83.
; DR PDB; 1LH4; 31-MAY-84.
; DR PDB; 2LH4; 31-MAY-84.
; DR PDB; 1LH5; 30-SEP-83.
; DR PDB; 2LH5; 30-SEP-83.
; DR PDB; 1LH6; 30-SEP-83.
; DR PDB; 2LH6; 30-SEP-83.
; DR PDB; 1LH7; 14-JUL-86.
; DR PDB; 2LH7; 14-JUL-86.
; DR PROSITE; PS00208; PLANT_GLOBIN.
; DR PROSITE; PS01033; GLOBIN.
; KW HEME; OXYGEN TRANSPORT; RESPIRATORY PROTEIN; NITROGEN FIXATION;
; KW 3D-STRUCTURE; MULTIGENE FAMILY.
; FT METAL 63 63 IRON (HEME DISTAL LIGAND)
; FT (BY SIMILARITY).
; FT METAL 97 97 IRON (HEME PROXIMAL LIGAND)
; FT (BY SIMILARITY).
; FT CONFLICT 61 61 Q -> AS (IN G168326).
; FT CONFLICT 79 79 Q -> E (IN REF. 1).
; FT CONFLICT 86 86 T -> S (IN REF. 1).
; FT CONFLICT 150 150 N -> D (IN REF. 1).
; FT HELIX 5 19
; FT TURN 20 21
; FT HELIX 22 36
; FT HELIX 38 43
; FT TURN 45 49
; FT HELIX 58 81
; FT HELIX 88 99
; FT TURN 100 101
; FT HELIX 104 125
; FT HELIX 128 152
; SQ SEQUENCE 153 AA; 16652 MW; 245B6A7B CRC32;
;
; LGB2_LUPLU Length: 153 April 15, 1997 16:43 Type: P Check: 8272 ..
lgb2luplu
GALTESQAALVKSSWEEFNANIPKHTHRFFILVLEIAPAAKDLFSFLKGTSEVPQNNPELQAHAGKVFKL
VYEAAIQLQVTGVVVTDATLKNLGSVHVSKGVADAHFPVVKEAILKTIKEVVGAKWSEELNSAWTIAYDE
LAIVIKKEMNDAA1
; TOIG of: myg_phyca check: 3184 from: 1 to: 153
;
; ID MYG_PHYCA STANDARD; PRT; 153 AA.
; AC P02185;
; DT 21-JUL-1986 (REL. 01, CREATED)
; DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE)
; DT 01-FEB-1995 (REL. 31, LAST ANNOTATION UPDATE)
; DE MYOGLOBIN.
; OS PHYSETER CATODON (SPERM WHALE) (PHYSETER MACROCEPHALUS).
; OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
; OC EUTHERIA; CETACEA.
; RN [1]
; RP SEQUENCE.
; RC TISSUE=SKELETAL MUSCLE;
; RA ROMERO-HERRERA A.E., LEHMANN H.;
; RL BIOCHIM. BIOPHYS. ACTA 336:318-323(1974).
; RN [2]
; RP SEQUENCE.
; RC TISSUE=HEART MUSCLE;
; RA EDMUNDSON A.B.;
; RL NATURE 205:883-887(1965).
; RN [3]
; RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF METMYOGLOBIN.
; RX MEDLINE; 77144097.
; RA TAKANO T.;
; RL J. MOL. BIOL. 110:537-568(1977).
; RN [4]
; RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF DEOXYMYOGLOBIN.
; RX MEDLINE; 77144098.
; RA TAKANO T.;
; RL J. MOL. BIOL. 110:569-584(1977).
; RN [5]
; RP X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF OXYMYOGLOBIN.
; RX MEDLINE; 81119812.
; RA PHILLIPS S.E.V.;
; RL J. MOL. BIOL. 142:531-554(1980).
; RN [6]
; RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
; RX MEDLINE; 91132649.
; RA LIONETTI C., GUANZIROLI M.G., FRIGERIO F., ASCENZI P., BOLOGNESI M.;
; RL J. MOL. BIOL. 217:409-412(1991).
; CC -!- FUNCTION: SERVES A RESERVE SUPPLY OF OXYGEN AND FACILITATES
; CC THE MOVEMENT OF OXYGEN WITHIN MUSCLES.
; DR PIR; A02506; MYWHP.
; DR PDB; 2MB5; 15-APR-91.
; DR PDB; 1MBC; 09-JAN-89.
; DR PDB; 1MBD; 27-OCT-83.
; DR PDB; 1MBI; 15-OCT-91.
; DR PDB; 1MBN; 27-OCT-83.
; DR PDB; 4MBN; 12-JUL-89.
; DR PDB; 5MBN; 12-JUL-89.
; DR PDB; 1MBO; 30-SEP-83.
; DR PDB; 1MBW; 15-OCT-90.
; DR PDB; 1FCS; 31-OCT-93.
; DR PDB; 1SWM; 31-JAN-94.
; DR PDB; 2CMM; 31-JAN-94.
; DR PDB; 1MGN; 31-JAN-94.
; DR PDB; 1MYM; 31-JAN-94.
; DR PDB; 2MGA; 31-JAN-94.
; DR PDB; 2MGB; 31-JAN-94.
; DR PDB; 2MGC; 31-JUL-94.
; DR PDB; 2MGD; 31-JUL-94.
; DR PDB; 2MGE; 31-JUL-94.
; DR PDB; 2MGF; 31-JUL-94.
; DR PDB; 2MGG; 31-JUL-94.
; DR PDB; 2MGH; 31-JUL-94.
; DR PDB; 2MGI; 31-JUL-94.
; DR PDB; 2MGJ; 31-JUL-94.
; DR PDB; 2MGK; 31-JUL-94.
; DR PDB; 2MGL; 31-JUL-94.
; DR PDB; 2MGM; 31-JUL-94.
; DR PDB; 2MYA; 31-JAN-94.
; DR PDB; 2MYB; 31-JAN-94.
; DR PDB; 2MYC; 31-JAN-94.
; DR PDB; 2MYD; 31-JAN-94.
; DR PDB; 2MYE; 31-JAN-94.
; DR PDB; 2SPL; 31-JAN-94.
; DR PDB; 2SPM; 31-JAN-94.
; DR PDB; 2SPN; 31-JAN-94.
; DR PDB; 2SPO; 31-JAN-94.
; DR PDB; 1MLF; 31-AUG-94.
; DR PDB; 1MLG; 31-AUG-94.
; DR PDB; 1MLH; 31-AUG-94.
; DR PDB; 1MLJ; 31-AUG-94.
; DR PDB; 1MLK; 31-AUG-94.
; DR PDB; 1MLL; 31-AUG-94.
; DR PDB; 1MLM; 31-AUG-94.
; DR PDB; 1MLN; 31-AUG-94.
; DR PDB; 1MLO; 31-AUG-94.
; DR PDB; 1MLR; 31-AUG-94.
; DR PDB; 1MLS; 31-AUG-94.
; DR PDB; 1MLU; 31-AUG-94.
; DR PROSITE; PS01033; GLOBIN.
; KW HEME; OXYGEN TRANSPORT; RESPIRATORY PROTEIN; MUSCLE; 3D-STRUCTURE.
; FT METAL 64 64 IRON (HEME DISTAL LIGAND).
; FT METAL 93 93 IRON (HEME PROXIMAL LIGAND).
; FT VARIANT 121 121 G -> A (IN METMYOGLOBIN).
; FT CONFLICT 122 122 D -> N (IN REF. 2).
; FT HELIX 4 35
; FT HELIX 37 42
; FT TURN 44 48
; FT HELIX 52 57
; FT HELIX 59 77
; FT TURN 78 80
; FT HELIX 83 95
; FT TURN 96 96
; FT HELIX 101 118
; FT HELIX 120 122
; FT HELIX 125 149
; FT TURN 150 150
; SQ SEQUENCE 153 AA; 17200 MW; E3C9BA11 CRC32;
;
; MYG_PHYCA Length: 153 April 15, 1997 16:43 Type: P Check: 3184 ..
mygphyca
VLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPETLEKFDRFKHLKTEAEMKASEDLKKHGVTVLT
ALGAILKKKGHHEAELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRK
DIAAKYKELGYQG1